caa a22 4500 475803787 CHVBK 20180406123745.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s002680010228 doi (NATIONALLICENCE)springer-10.1007/s002680010228 Iatrogenic Thyrotoxicosis: Causal Circumstances, Pathophysiology, and Principles of Treatment—Review of the Literature [Elektronische Daten] [Michel Meurisse, Laragh Gollogly, Cyrille Degauque, Isabelle Fumal, Thierry Defechereux, Etienne Hamoir] Thyrotoxicosis is the clinical syndrome that results when tissues are exposed to high levels of circulating thyroid hormones. In most instances thyrotoxicosis is due to hyperthyroidism, a term reserved for disorders characterized by overproduction of thyroid hormones by the thyroid gland. Nevertheless, thyrotoxicosis may also result from a variety of conditions other than thyroid hyperfunction. The present report focuses on the etiologies, pathophysiology, and treatment of iatrogenic thyrotoxicosis. Iatrogenic thyrotoxicosis may be caused by (1) subacute thyroiditis (a result of lymphocytic infiltration, cellular injury, trauma, irradiation) with release of preformed hormones into circulation; (2) excessive ingestion of thyroid hormones ("thyrotoxicosis factitia”); (3) iodine-induced hyperthyroidism (radiologic contrast agents, topical antiseptics, other medications). Among these causes of iatrogenic thyrotoxicosis, that induced by the iodine overload and cytotoxicity associated with amiodarone represents a significant challenge. Successful management of amiodarone-induced thyrotoxicosis requires close cooperation between endocrinologists and endocrine surgeons. Surgical treatment may have a leading yet often underestimated role in view of the potential life-threatening severity of this disease, whereas others kinds of iatrogenic thyrotoxicosis are usually treated conservatively. Société Internationale de Chirurgie, 2000 Meurisse Michel Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium, BE aut Gollogly Laragh Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium, BE aut Degauque Cyrille Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium, BE aut Fumal Isabelle Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium, BE aut Defechereux Thierry Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium, BE aut Hamoir Etienne Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium, BE aut World Journal of Surgery Springer-Verlag 24/11(2000-11-01), 1377-1385 0364-2313 24:11<1377 2000 24 268 https://doi.org/10.1007/s002680010228 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002680010228 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meurisse Michel Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium, BE aut NATIONALLICENCE 700 1- Gollogly Laragh Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium, BE aut NATIONALLICENCE 700 1- Degauque Cyrille Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium, BE aut NATIONALLICENCE 700 1- Fumal Isabelle Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium, BE aut NATIONALLICENCE 700 1- Defechereux Thierry Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium, BE aut NATIONALLICENCE 700 1- Hamoir Etienne Department of Endocrine Surgery and Transplantation, Centre Hospitalier Universitaire de Liège, B35, Domaine Universitaire du Sart-Tilman, 4000 Liege, Belgium, BE aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 24/11(2000-11-01), 1377-1385 0364-2313 24:11<1377 2000 24 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer