caa a22 4500 475805984 CHVBK 20180406123747.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1026537423753 doi (NATIONALLICENCE)springer-10.1023/A:1026537423753 An Inducible Melanoma Model Implicates a Role for RAS in Tumor Maintenance and Angiogenesis [Elektronische Daten] [Alex Wong, Lynda Chin] The established tumor is maintained through complex and poorly understood host-tumor interactions guiding processes such as angiogenesis. The numerous and diverse genetic alterations that accompany tumor genesis raises questions as to whether experimental cancer-promoting mutations remain relevant to tumor maintenance. Utilizing a new doxycycline-inducible H-RASV12G INK4a null mouse melanoma model, we have shown that melanoma genesis and maintenance are strictly dependent upon H-RASV12G expression. Withdrawal of doxycycline and H-RASV12G down-regulation resulted in clinical and histological regression of primary and explanted tumors. Moreover, the initial stages of regression were highlighted by dramatic activation of apoptosis in the tumor cells as well as host-derived endothelial cells. These data provide genetic evidence that H-RASV12G plays a critical role in tumor maintenance and tumor angiogenesis Kluwer Academic Publishers, 2000 mouse model nationallicence melanoma nationallicence RAS nationallicence tumor maintenance nationallicence angiogenesis nationallicence Wong Alex Department of Adult Oncology, Dana-Farber Cancer Institute, MA, USA aut Chin Lynda Department of Adult Oncology, Dana-Farber Cancer Institute, MA, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 121-129 0167-7659 19:1-2<121 2000 19 10555 https://doi.org/10.1023/A:1026537423753 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026537423753 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wong Alex Department of Adult Oncology, Dana-Farber Cancer Institute, MA, USA aut NATIONALLICENCE 700 1- Chin Lynda Department of Adult Oncology, Dana-Farber Cancer Institute, MA, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 121-129 0167-7659 19:1-2<121 2000 19 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer