caa a22 4500 47580600X CHVBK 20180406123747.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1026510130114 doi (NATIONALLICENCE)springer-10.1023/A:1026510130114 Role of the Tumor Microenvironment in Mediating Response to Anti-angiogenic Therapy [Elektronische Daten] [Young Jung, Syed Ahmad, Yoshito Akagi, Yutaka Takahashi, Wenbiao Liu, Niels Reinmuth, Raymond Shaheen, Fan Fan, Lee Ellis] Despite the development of innovative anti-angiogenic strategies, early clinical trials have not replicated the results observed from preclinical models. One reason for this apparent discrepancy is the fact that tumor endothelium is phenotypically distinct from normal tissue endothelium. Moreover, it has recently become apparent that each individual tumor may display a different angiogenic phenotype. The expression of angiogenic factors in tumors is controlled by both intrinsic factors in the tumor cell and the influence of the host microenvironment. The diversity of angiogenic factor expression in tumors growing at different sites, combined with the fact that endothelial cells in different organs and tumors are phenotypically distinct, constitutes a formidable challenge for the development of effective anti-angiogenic regimens. This review provides an overview of how the microenvironment regulates tumor angiogenesis and affects the efficacy of anti-angiogenic therapy. Kluwer Academic Publishers, 2000 microenvironment nationallicence angiogenesis nationallicence anti-angiogenesis nationallicence heterogeneity nationallicence vascular endothelial growth factor nationallicence endothelial cells nationallicence Jung Young Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut Ahmad Syed Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut Akagi Yoshito Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut Takahashi Yutaka Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut Liu Wenbiao Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut Reinmuth Niels Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut Shaheen Raymond Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut Fan Fan Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut Ellis Lee Department of Cancer Biology; Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 147-157 0167-7659 19:1-2<147 2000 19 10555 https://doi.org/10.1023/A:1026510130114 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026510130114 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jung Young Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Ahmad Syed Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Akagi Yoshito Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Takahashi Yutaka Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Liu Wenbiao Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Reinmuth Niels Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Shaheen Raymond Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Fan Fan Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Ellis Lee Department of Cancer Biology; Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 147-157 0167-7659 19:1-2<147 2000 19 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer