caa a22 4500 475806026 CHVBK 20180406123747.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1026579711033 doi (NATIONALLICENCE)springer-10.1023/A:1026579711033 Neuropilin is a Mediator of Angiogenesis [Elektronische Daten] [Hua-Quan Miao, Michael Klagsbrun] Neuropilin is both a receptor for semaphorins, which are mediators of neuronal guidance, and for VEGF, an angiogenesis factor. While the function of neuropilin in the nervous system has been characterized, its role in angiogenesis is only beginning to be elucidated. This article reviews some of the structural and functional features of neuropilin and presents the experimental evidence showing that it is a mediator of angiogenesis. In particular, we show that neuropilin and its soluble isoforms regulate tumor angiogenesis and subsequent tumor growth Kluwer Academic Publishers, 2000 VEGF nationallicence semaphorins nationallicence VEGF receptors nationallicence plexin nationallicence tumor angiogenesis nationallicence Miao Hua-Quan Department of Surgical Research, Children's Hospital and Harvard Medical School, Boston, MA, USA aut Klagsbrun Michael Department of Surgical Research; Department of Pathology, Children's Hospital and Harvard Medical School, Boston, MA, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 29-37 0167-7659 19:1-2<29 2000 19 10555 https://doi.org/10.1023/A:1026579711033 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026579711033 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miao Hua-Quan Department of Surgical Research, Children's Hospital and Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 700 1- Klagsbrun Michael Department of Surgical Research; Department of Pathology, Children's Hospital and Harvard Medical School, Boston, MA, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 29-37 0167-7659 19:1-2<29 2000 19 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer