caa a22 4500 475806034 CHVBK 20180406123747.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1026543018478 doi (NATIONALLICENCE)springer-10.1023/A:1026543018478 2-Methoxyestradiol: an Endogenous Antiangiogenic and Antiproliferative Drug Candidate [Elektronische Daten] [Victor Pribluda, Edward Gubish, Edward Gubish, Theresa LaVallee, Anthony Treston, Glenn Swartz, Shawn Green] 2-Methoxyestradiol, once considered an inacitve end-metabolite of estradiol, has recently emerged as a very promising agent for cancer treatment. It is orally active in a wide range of tumor models, and inhibits tumor growth at doses showing non clinical signs of toxicity. 2ME2 targets both the tumor cell and endothelial cell compartments by inducing apoptosis in rapidly proliferating cells and inhibiting blood vessel formation at several stages in the angiogenic cascade. Moreover, the ability of 2ME2 to inhibit metastic spread in several models adds to its therapeutic value for cancer treatment at various stages of the disease. Though the mechanism of action is still undefined, several potential molecular targets and pathways of activation have been suggested. Kluwer Academic Publishers, 2000 2-methoxyestradiol nationallicence angiogenesis nationallicence endothelial cells nationallicence antiangiogenic therapy nationallicence cancer steroid nationallicence Pribluda Victor EntreMed Inc., Rockville, MD, USA aut Gubish Edward EntreMed Inc., Rockville, MD, USA aut LaVallee Theresa EntreMed Inc., Rockville, MD, USA aut Treston Anthony EntreMed Inc., Rockville, MD, USA aut Swartz Glenn EntreMed Inc., Rockville, MD, USA aut Green Shawn EntreMed Inc., Rockville, MD, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 173-179 0167-7659 19:1-2<173 2000 19 10555 https://doi.org/10.1023/A:1026543018478 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026543018478 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pribluda Victor EntreMed Inc., Rockville, MD, USA aut NATIONALLICENCE 700 1- Gubish Edward EntreMed Inc., Rockville, MD, USA aut NATIONALLICENCE 700 1- LaVallee Theresa EntreMed Inc., Rockville, MD, USA aut NATIONALLICENCE 700 1- Treston Anthony EntreMed Inc., Rockville, MD, USA aut NATIONALLICENCE 700 1- Swartz Glenn EntreMed Inc., Rockville, MD, USA aut NATIONALLICENCE 700 1- Green Shawn EntreMed Inc., Rockville, MD, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 173-179 0167-7659 19:1-2<173 2000 19 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer