caa a22 4500 475806042 CHVBK 20180406123747.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1026555121511 doi (NATIONALLICENCE)springer-10.1023/A:1026555121511 Tek/Tie2 Signaling: New and Old Partners [Elektronische Daten] [Nina Jones, Daniel Dumont] A common property amongst angiogenic ligands such as the vascular endothelial growth factors and the angiopoietins is that they can elicit multiple responses depending upon the context of their expression and the presence of other growth factors. Study of the signal transduction pathways initiated by these growth factors provides insight into the molecular and cellular mechanisms that regulate vessel assembly. Key components of signal transduction cascades can then be used as potential targets in angiogenic therapies. This commentary reviews the recent advances into understanding the molecular signaling pathways mediated through the angiopoietin receptor, Tek/Tie2, as well as their effect on the regulation of distinct cellular aspects of angiogenesis. Kluwer Academic Publishers, 2000 Tek/Tie2 nationallicence angiopoietin nationallicence angiogenesis nationallicence signal transduction nationallicence Jones Nina Division of Cancer Biology Research, Sunnybrook and Women's College Health Sciences Centre; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada aut Dumont Daniel Division of Cancer Biology Research, Sunnybrook and Women's College Health Sciences Centre; Toronto-Sunnybrook Regional Cancer Centre; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada aut Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 13-17 0167-7659 19:1-2<13 2000 19 10555 https://doi.org/10.1023/A:1026555121511 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026555121511 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jones Nina Division of Cancer Biology Research, Sunnybrook and Women's College Health Sciences Centre; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Dumont Daniel Division of Cancer Biology Research, Sunnybrook and Women's College Health Sciences Centre; Toronto-Sunnybrook Regional Cancer Centre; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 13-17 0167-7659 19:1-2<13 2000 19 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer