caa a22 4500 475806050 CHVBK 20180406123747.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1026540129688 doi (NATIONALLICENCE)springer-10.1023/A:1026540129688 Carbohydrate-Recognition and Angiogenesis [Elektronische Daten] [Pratima Nangia-Makker, Sara Baccarini, Avraham Raz] Angiogenesis is required for the continual growth of the tumor and provides a gateway for cells to escape the confines of the primary tumor. Angiogenic stimulus triggers a cascade of functional responses leading to local basement membrane dissolution, endothelial cell migration, proliferation and microvessel morphogenesis. In this commentary, we review the significance of carbohydrate-binding proteins involved in angiogenesis. The importance of carbohydrate-recognition processes to angiogenesis stems from the observation that angiogenic factors like fibroblast growth factor family and vascular endothelial growth factors bind initially to the extracellular matrix proteoglycans before binding to their cognate receptors, and some of the adhesion molecules bind to glycoconjugates present on the surface of the endothelial cells. The possible significance of these interactions will be discussed. Kluwer Academic Publishers, 2000 neovascularization nationallicence proteoglycans nationallicence glycoproteins nationallicence adhesion molecules nationallicence angiogenic factors nationallicence Nangia-Makker Pratima Tumor Progression and Metastasis, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA aut Baccarini Sara Tumor Progression and Metastasis, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA aut Raz Avraham Tumor Progression and Metastasis, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 51-57 0167-7659 19:1-2<51 2000 19 10555 https://doi.org/10.1023/A:1026540129688 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026540129688 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nangia-Makker Pratima Tumor Progression and Metastasis, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA aut NATIONALLICENCE 700 1- Baccarini Sara Tumor Progression and Metastasis, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA aut NATIONALLICENCE 700 1- Raz Avraham Tumor Progression and Metastasis, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 51-57 0167-7659 19:1-2<51 2000 19 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer