caa a22 4500 475806069 CHVBK 20180406123747.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1026552415576 doi (NATIONALLICENCE)springer-10.1023/A:1026552415576 Benjamin Laura Beth Israel Deaconess Medical Center, Harvard Medical School, Research North, Boston, MA, USA aut The Controls of Microvascular Survival [Elektronische Daten] [Laura Benjamin] The regulation of microvascular survival impacts both developmental remodeling of the vasculature, and various microvascular pathologies. In pathological settings of vascular insufficiency, molecular targets to affect stabilization of neovascularization are needed. Conversely, an important part of anti-tumor angiogenesis is the de-stabilization of the tumor vasculature. In the study of vascular remodeling, one difficult challenge is to understand the molecular controls that allow regression of one entire vessel segment and not another. This phenomenon requires coordination of the survival signaling pathways to successfully impact vascular structure. This review describes the known mechanisms and molecules involved in microvascular and endothelial cell survival. In particular the mechanisms of molecular signaling for survival in vitro are discussed in light of what is known about microvascular survival in vivo. Possible ways to bring these data together to explain the complex regulation of vessel survival are discussed. Kluwer Academic Publishers, 2000 endothelial cell nationallicence angiogenesis nationallicence survival nationallicence apoptosis nationallicence VEGF-A nationallicence pericyte nationallicence Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 75-81 0167-7659 19:1-2<75 2000 19 10555 https://doi.org/10.1023/A:1026552415576 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026552415576 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Benjamin Laura Beth Israel Deaconess Medical Center, Harvard Medical School, Research North, Boston, MA, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 75-81 0167-7659 19:1-2<75 2000 19 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer