caa a22 4500 475806093 CHVBK 20180406123747.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1026560618302 doi (NATIONALLICENCE)springer-10.1023/A:1026560618302 Volpert O.V. Department of Urology and R.H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL, USA aut Modulation of Endothelial Cell Survival by an Inhibitor of Angiogenesis Thrombospondin-1: a Dynamic Balance [Elektronische Daten] [O.V. Volpert] Angiogenesis is a process of capillary formation from pre-existing blood vessels. It is tightly controlled by the balance between positive and negative environmental signals - inducers and inhibitors of angiogenesis in such a way that predominance of inducers results in angiogenesis and predominance of inhibitors - in vascular quiescence. Here we discuss the ability of the angiogenic stimuli to promote survival and the pathways they may utilize. We also summarize information available on the signaling events elicited in the endothelial cells by a naturally occurring inhibitor of angiogenesis Thrombospondin-1 (TSP-1), that result in the endothelial cell apoptosis and inhibition of angiogenesis in vivo. This ability to cause programmed cell death in vascular endothelium is not unique to TSP-1. A substantial number of known angiogenesis inhibitors can also trigger apoptosis in the activated endothelial cells. This fact argues for the possibility of apoptosis to be a common denominator for a major fraction of anti-angiogenic molecules. If this is the case, it is equally possible that the ratio between environmental factors that control angiogenesis is interpreted within individual endothelial cell as a balance between pro-apoptotic and survival signals. Thus the relative strength of the death and survival signal or signals determines the fate of endothelial cell and therefore the fate of remodeling vessel. Kluwer Academic Publishers, 2000 angiogenesis nationallicence endothelial cell survival nationallicence apoptosis nationallicence thrombospondin-1 nationallicence Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 87-92 0167-7659 19:1-2<87 2000 19 10555 https://doi.org/10.1023/A:1026560618302 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026560618302 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Volpert O.V. Department of Urology and R.H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 87-92 0167-7659 19:1-2<87 2000 19 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer