caa a22 4500 475806115 CHVBK 20180406123747.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1026541510549 doi (NATIONALLICENCE)springer-10.1023/A:1026541510549 Ultrasound for the Visualization and Quantification of Tumor Microcirculation [Elektronische Daten] [F. Stuart Foster, Peter Burns, David Simpson, Stephanie Wilson, Donald Christopher, David Goertz] Advances in ultrasound based methods for the non-invasive assessment of the tumor microcirculation are described. Two new ultrasound approaches are highlighted. The first method relies on commercially available ultrasound contrast agents in combination with specialized nonlinear imaging sequences. Nonlinear scattering by microbubble contrast agents provides a unique intravascular signature that can be distinguished from the echoes caused by surrouning tissues. Through destruction-reperfusion experiments it is possible to use microbubble contrast agents as a tracer revealing the kinetics of tumor blood flow. The second ultrasound method for examining the microcirculation involves the use of much higher frequencies. At frequencies on the order of 50 MHz, Doppler processing allows the direct assessment of flow dynamics in realtime in arterioles as small as 15 µm. Three dimensional Doppler maps of flow patterning are presented. The strengths and weaknesses of these new methods are discussed and the potential for their use in preclinical animal drug studies, clinical drug trials, and prognostic studies is described. Kluwer Academic Publishers, 2000 angiogensis nationallicence microcirculation nationallicence ultrasound nationallicence microbubble contrast agents nationallicence blood flow visualization nationallicence Doppler ultrasound nationallicence high frequency ultrasound nationallicence ultrasound biomicroscopy nationallicence three dimensional imaging nationallicence Stuart Foster F. Sunnybrook and Women's College Health Sciences Centre and The University of Toronto, Canada aut Burns Peter Sunnybrook and Women's College Health Sciences Centre and The University of Toronto, Canada aut Simpson David Sunnybrook and Women's College Health Sciences Centre and The University of Toronto, Canada aut Wilson Stephanie Department of Medical Imaging, The University of Toronto, University Health Network, Toronto, Ontario, Canada aut Christopher Donald Sunnybrook and Women's College Health Sciences Centre and The University of Toronto, Canada aut Goertz David Sunnybrook and Women's College Health Sciences Centre and The University of Toronto, Canada aut Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 131-138 0167-7659 19:1-2<131 2000 19 10555 https://doi.org/10.1023/A:1026541510549 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026541510549 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stuart Foster F. Sunnybrook and Women's College Health Sciences Centre and The University of Toronto, Canada aut NATIONALLICENCE 700 1- Burns Peter Sunnybrook and Women's College Health Sciences Centre and The University of Toronto, Canada aut NATIONALLICENCE 700 1- Simpson David Sunnybrook and Women's College Health Sciences Centre and The University of Toronto, Canada aut NATIONALLICENCE 700 1- Wilson Stephanie Department of Medical Imaging, The University of Toronto, University Health Network, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Christopher Donald Sunnybrook and Women's College Health Sciences Centre and The University of Toronto, Canada aut NATIONALLICENCE 700 1- Goertz David Sunnybrook and Women's College Health Sciences Centre and The University of Toronto, Canada aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 131-138 0167-7659 19:1-2<131 2000 19 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer