caa a22 4500 475806158 CHVBK 20180406123747.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1026551202548 doi (NATIONALLICENCE)springer-10.1023/A:1026551202548 Angiostatin and Endostatin: Endogenous Inhibitors of Tumor Growth [Elektronische Daten] [B. Kim Lee Sim, Nicholas MacDonald, Edward Gubish] Considerable progress has been made in the understanding of the molecular structure and mechanistic aspects of Angiostatin and Endostatin, endogenous angiogenesis inhibitors that have been shown to regress tumors in murine models. The growing body of literature surrounding these molecules and on the efficacy of these proteins is in part due to the ability to generate these proteins in recombinant systems as well characterized molecules. Recombinant human Angiostatin and Endostatin are in Phase I trials, following the manufacture of clinical grade material at large scale. This review highlights the recent advances made on understanding the structure and function of Angiostatin and Endostatin. Kluwer Academic Publishers, 2000 antiangiogenesis nationallicence Angiostatin nationallicence Endostatin nationallicence Kim Lee Sim B. EntreMed Inc., Rockville, MD, USA aut MacDonald Nicholas EntreMed Inc., Rockville, MD, USA aut Gubish Edward EntreMed Inc., Rockville, MD, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 181-190 0167-7659 19:1-2<181 2000 19 10555 https://doi.org/10.1023/A:1026551202548 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026551202548 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Lee Sim B. EntreMed Inc., Rockville, MD, USA aut NATIONALLICENCE 700 1- MacDonald Nicholas EntreMed Inc., Rockville, MD, USA aut NATIONALLICENCE 700 1- Gubish Edward EntreMed Inc., Rockville, MD, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 181-190 0167-7659 19:1-2<181 2000 19 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer