caa a22 4500 475806166 CHVBK 20180406123747.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1023/A:1026538601947 doi (NATIONALLICENCE)springer-10.1023/A:1026538601947 Role of Incipient Angiogenesis in Cancer Metastasis [Elektronische Daten] [Chuan Yuan Li, Siqing Shan, Yiting Cao, Mark Dewhirst] Metastasis is the primary cause of mortality in cancer patients. Angiogenesis is intimately involved in metastasis at the site of entry of tumor cells into the vasculature and at the site of eventual metastasis growth. In this commentary, we review current paradigms regarding angiogenesis in metastatic sites. Recent discoveries challenge some of the existing paradigms. Significant prior data suggest that successful formation of metastases requires: 1) angiogenesis in the primary tumor site; 2) downregulation of cohesive molecules and tumor cell increased motility, resulting in invasion into neovessels; 3) tumor cell embolism; 4) arrest and attachment in capillary beds of distant organs; 5) extravasation and proliferation in the organ parenchyma; and 6) re-establishment of angiogenesis when the tumor reaches >1-2 mm in size [1]. While most recent data largely confirm the aforementioned sequence of events, a few reports have revealed new knowledge about the earliest phases of angiogenesis of metastases. Of particular importance has been the ability to create tumor cell lines that are stably transfected with reporter genes, such as green fluorescence protein. With these tools it is now literally possible to monitor tumor formation from a single cell [2-7]. Kluwer Academic Publishers, 2000 angiogenesis nationallicence metastasis nationallicence microenvironment nationallicence reporter gene nationallicence greenfluorescent protein nationallicence Yuan Li Chuan Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA aut Shan Siqing Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA aut Cao Yiting Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA aut Dewhirst Mark Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 7-11 0167-7659 19:1-2<7 2000 19 10555 https://doi.org/10.1023/A:1026538601947 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026538601947 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yuan Li Chuan Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA aut NATIONALLICENCE 700 1- Shan Siqing Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA aut NATIONALLICENCE 700 1- Cao Yiting Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA aut NATIONALLICENCE 700 1- Dewhirst Mark Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 19/1-2(2000-06-01), 7-11 0167-7659 19:1-2<7 2000 19 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer