caa a22 4500 475811259 CHVBK 20180406123759.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s001920070009 doi (NATIONALLICENCE)springer-10.1007/s001920070009 Serotonergic Antidepressants and Urinary Incontinence [Elektronische Daten] [N. A. Votolato, S. Stern, R. M. Caputo] Many new serotonergic antidepressants have been introduced over the past decade. Although urinary incontinence is listed as one side effect of these drugs in their package inserts there is only one report in the literature. This concerns 2 male patients who experienced incontinence while taking venlafaxine. In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine. In 2 of the 3 cases the patients were also taking lithium carbonate and β-blockers, both of which could have contributed to the incontinence. Animal studies suggest that incontinence secondary to serotonergic antidepressants could be mediated by the 5HT4 receptors found on the bladder. Further research is needed to delineate the frequency of this troubling side effect and how best to treat it. Springer-Verlag London Limited, 2000 Key words:Antidepressants - Serotonin - Urinary incontinence nationallicence Votolato N. A. Department of Psychiatry and Pharmacy, Ohio State University, US aut Stern S. University of Texas, Health Science Center At San Antonio; San Antonio, Texas, US aut Caputo R. M. Division of Urogynecology and Pelvic Floor Reconstructive Surgery, Ohio State University, Columbus, Ohio, USA, US aut International Urogynecology Journal Springer-Verlag 11/6(2000-11-01), 386-388 0937-3462 11:6<386 2000 11 192 https://doi.org/10.1007/s001920070009 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s001920070009 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Votolato N. A. Department of Psychiatry and Pharmacy, Ohio State University, US aut NATIONALLICENCE 700 1- Stern S. University of Texas, Health Science Center At San Antonio; San Antonio, Texas, US aut NATIONALLICENCE 700 1- Caputo R. M. Division of Urogynecology and Pelvic Floor Reconstructive Surgery, Ohio State University, Columbus, Ohio, USA, US aut NATIONALLICENCE 773 0- International Urogynecology Journal Springer-Verlag 11/6(2000-11-01), 386-388 0937-3462 11:6<386 2000 11 192 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer