caa a22 4500 475811763 CHVBK 20180406123801.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/PL00004024 doi (NATIONALLICENCE)springer-10.1007/PL00004024 Effect of Estrogen-Progestogen Hormonal Replacement Therapy on Periurethral and Bladder Vessels [Elektronische Daten] [R. M. Endo, M. J. B. C. Girão, M. G. F. Sartori, M. J. Simões, E. C. Baracat, G. Rodrigues de Lima] Abstract:: This study assessed the effect of hormone replacement therapy using estrogens and/or progestogens on the number of vessels in the proximal and distal urethra, vesicourethral junction and bladder of castrated adult female rats. Forty-five virgin adult rats (Rattus norvegicus albinus) castrated for at least 30 days were used. They were assigned to five groups; group I (control) received no medication; the others received via the subcutaneous route, respectively, 17-β-estradiol (group II), medroxyprogesterone acetate (group III), a maize oil and benzyl acid solution - placebo (group IV) and 17-β-estradiol combined with medroxyprogesterone acetate (group V), for a minimum of 28 days. Increased vascularization throughout the urinary tract, except in the distal urethra, was found following estrogen replacement alone. In the group that received combined estrogens and progestogens, no increase was found. It was concluded that estrogen replacement in castrated rats significantly increased the number of vessels in the lower urinary tract. Springer-Verlag London Limited, 2000 Key words:Hypoestrogenism - Stress urinary incontinence - Urethral vessels nationallicence Endo R. M. Escola Paulista de Medicina, Sâo Paulo, Brazil, BR aut Girão M. J. B. C. Escola Paulista de Medicina, Sâo Paulo, Brazil, BR aut Sartori M. G. F. Escola Paulista de Medicina, Sâo Paulo, Brazil, BR aut Simões M. J. Escola Paulista de Medicina, Sâo Paulo, Brazil, BR aut Baracat E. C. Escola Paulista de Medicina, Sâo Paulo, Brazil, BR aut Rodrigues de Lima G. Escola Paulista de Medicina, Sâo Paulo, Brazil, BR aut https://doi.org/10.1007/PL00004024 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00004024 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Endo R. M. Escola Paulista de Medicina, Sâo Paulo, Brazil, BR aut NATIONALLICENCE 700 1- Girão M. J. B. C. Escola Paulista de Medicina, Sâo Paulo, Brazil, BR aut NATIONALLICENCE 700 1- Sartori M. G. F. Escola Paulista de Medicina, Sâo Paulo, Brazil, BR aut NATIONALLICENCE 700 1- Simões M. J. Escola Paulista de Medicina, Sâo Paulo, Brazil, BR aut NATIONALLICENCE 700 1- Baracat E. C. Escola Paulista de Medicina, Sâo Paulo, Brazil, BR aut NATIONALLICENCE 700 1- Rodrigues de Lima G. Escola Paulista de Medicina, Sâo Paulo, Brazil, BR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer