caa a22 4500 475815327 CHVBK 20180406123808.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1026560806158 doi (NATIONALLICENCE)springer-10.1023/A:1026560806158 Impact of chlorine and acidification in the electrochemical treatment of tumours [Elektronische Daten] [E. Nilsson, J. Berendson, E. Fontes] Electrochemical treatment (EChT) of tumours offers considerable promise as a safe, simple and relatively noninvasive antitumour therapy. When platinum is used as electrode material, the major electrochemical reactions at the anode are chlorine and oxygen evolution. Conflicting opinions can be found in the literature over the role of chlorine in the underlying destruction mechanism behind EChT. In this present study, the impact of chlorine in EChT treatments is investigated by means of mathematical modelling. The analysis focuses on the tissue surrounding a spherical platinum anode when applying a constant current density. Tissue is modelled as an aqueous solution of sodium chloride containing a bicarbonate buffer system and organic constituents susceptible to reactions with chlorine. Except for the case of very low anode current densities, the simulations clearly show that it is the spreading of hydrogen ions - and not chlorine molecules - that determines the extent of tissue destruction around the anode. Moreover, it is found that the reactions of chlorine with tissue play important roles as generators of hydrogen ions. The contribution of these reactions to the acidification of tissue, surrounding the anode, is strongly dependent on the applied current density and increases with decreasing current density. Kluwer Academic Publishers, 2000 chlorine nationallicence direct current nationallicence electrochemical treatment (EChT) nationallicence mathematical modelling nationallicence tumour nationallicence Nilsson E. Catella Generics AB Veddestavägen 7, SE-17562, Järfãlla, Sweden aut Berendson J. Catella Generics AB Veddestavägen 7, SE-17562, Järfãlla, Sweden aut Fontes E. Comsol AB, Tegnérgatan 23, SE-11140, Stockholm, Sweden aut Journal of Applied Electrochemistry Kluwer Academic Publishers 30/12(2000-12-01), 1321-1333 0021-891X 30:12<1321 2000 30 10800 https://doi.org/10.1023/A:1026560806158 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026560806158 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nilsson E. Catella Generics AB Veddestavägen 7, SE-17562, Järfãlla, Sweden aut NATIONALLICENCE 700 1- Berendson J. Catella Generics AB Veddestavägen 7, SE-17562, Järfãlla, Sweden aut NATIONALLICENCE 700 1- Fontes E. Comsol AB, Tegnérgatan 23, SE-11140, Stockholm, Sweden aut NATIONALLICENCE 773 0- Journal of Applied Electrochemistry Kluwer Academic Publishers 30/12(2000-12-01), 1321-1333 0021-891X 30:12<1321 2000 30 10800 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer