caa a22 4500 475817885 CHVBK 20180406123814.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1007/s002280050010 doi (NATIONALLICENCE)springer-10.1007/s002280050010 Effect of intravenous dopamine infusion on plasma concentrations of dopamine and dopamine sulfate in men, during and up to 18 h after infusion [Elektronische Daten] [A. Onasch, A. Tanzeem, F. Isgro, D. Böning, G. Strobel] Objective: We investigated whether sulfoconjugation contributes to the inactivation of intravenously infused dopamine (DA) in low concentrations with a predominant action on the kidney. Methods: Plasma DA and dopamine sulfate (DA-S) concentrations were determined during 4 h of intravenous infusion of DA (2 μg/kg/min) and up to 18 h after cessation of infusion. Twenty-seven healthy young subjects participated in the placebo controlled, randomised and double-blind study. Results: Intravenously administered DA was sulfoconjugated rapidly and to a great extent. After starting the infusion, DA levels rose within minutes and reached a steady state after 30-60 min. The steady-state levels averaged 151.3 ± 8.2 nmol/l. DA-S levels also increased markedly with infusion from 16.7 ± 9.9 nmol/l at the start of infusion up to 261.2 ± 24.2 nmol/l at 30 min after cessation of infusion. Plasma DA concentrations after cessation of the infusion decreased rapidly with an initial half-life of elimination of 4.8 min. Concentrations of plasma DA-S declined with a half-life of 4.5 h. Persistent elevations of free and conjugated DA compared with pre-treatment levels were observed even 18 h after cessation. Heart rate and blood pressure remained unchanged both during DA and saline infusion. Conclusion: Findings indicate that the sulfoconjugation pathway contributes markedly to the inactivation of intravenously infused DA and seems not to be saturable by DA infusion in low doses. Springer-Verlag Berlin Heidelberg, 2000 Key words Dopamine nationallicence Pharmacokinetics nationallicence Sulfoconjugation nationallicence Onasch A. Institute of Sports Medicine, Universitätsklinikum Benjamin Franklin, Free University Berlin, Clayallee 229, D-14195 Berlin, Germany e-mail: gstrobel@zedat.fu-berlin.de Tel.: +49-30-81812573; Fax: +49-30-81812572, DE aut Tanzeem A. Institute of Heart Surgery, Ruprecht Karls University, Heidelberg, Germany, DE aut Isgro F. Institute of Heart Surgery, Ludwigshafen, Germany, DE aut Böning D. Institute of Sports Medicine, Universitätsklinikum Benjamin Franklin, Free University Berlin, Clayallee 229, D-14195 Berlin, Germany e-mail: gstrobel@zedat.fu-berlin.de Tel.: +49-30-81812573; Fax: +49-30-81812572, DE aut Strobel G. Institute of Sports Medicine, Universitätsklinikum Benjamin Franklin, Free University Berlin, Clayallee 229, D-14195 Berlin, Germany e-mail: gstrobel@zedat.fu-berlin.de Tel.: +49-30-81812573; Fax: +49-30-81812572, DE aut https://doi.org/10.1007/s002280050010 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050010 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Onasch A. Institute of Sports Medicine, Universitätsklinikum Benjamin Franklin, Free University Berlin, Clayallee 229, D-14195 Berlin, Germany e-mail: gstrobel@zedat.fu-berlin.de Tel.: +49-30-81812573; Fax: +49-30-81812572, DE aut NATIONALLICENCE 700 1- Tanzeem A. Institute of Heart Surgery, Ruprecht Karls University, Heidelberg, Germany, DE aut NATIONALLICENCE 700 1- Isgro F. Institute of Heart Surgery, Ludwigshafen, Germany, DE aut NATIONALLICENCE 700 1- Böning D. Institute of Sports Medicine, Universitätsklinikum Benjamin Franklin, Free University Berlin, Clayallee 229, D-14195 Berlin, Germany e-mail: gstrobel@zedat.fu-berlin.de Tel.: +49-30-81812573; Fax: +49-30-81812572, DE aut NATIONALLICENCE 700 1- Strobel G. Institute of Sports Medicine, Universitätsklinikum Benjamin Franklin, Free University Berlin, Clayallee 229, D-14195 Berlin, Germany e-mail: gstrobel@zedat.fu-berlin.de Tel.: +49-30-81812573; Fax: +49-30-81812572, DE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer