caa a22 4500 475817982 CHVBK 20180406123814.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s002280050700 doi (NATIONALLICENCE)springer-10.1007/s002280050700 The efficacy of buffered ketoprofen in postoperative pain after third molar surgery [Elektronische Daten] [R. A. Seymour, H. Watkinson, J. E. Hawkesford, U. Moore] Objective: To evaluate in a randomised, double-blind, placebo-controlled trial, the efficacy (time to onset of meaningful pain relief) of single doses of buffered ketoprofen (12.5 mg) and ibuprofen (200 mg) in 180 patients with postoperative pain after third molar surgery. Methods: 180 adult patients who had undergone third molar surgery under general anaesthesia participated in this study. After dosing, patients recorded their time to meaningful pain relief, pain intensity on both visual analogue scales and verbal rating scales, pain relief and the need for additional analgesia. Pain recordings were made at fixed time points over a 6-h investigation period. Result: Buffered ketoprofen (12.5 mg) provided quicker meaningful pain relief than placebo (P=0.023). For secondary efficacy measures (SPIDS4, SPIDS6, TOTPAR4, TOTPAR6), the buffered ketoprofen was significantly superior to both placebo (P < 0.001) and ibuprofen (200 mg) (P < 0.05). Similarly, the amount of time before taking an escape analgesic was significantly less in the placebo group than both the ibuprofen and buffered ketoprofen groups (P < 0.03). Conclusions: Buffered ketoprofen (12.5 mg) provides effective pain control in the early postoperative period after third molar surgery. This ketoprofen preparation was also superior to ibuprofen (200 mg) with respect to both reducing pain intensity and providing an earlier onset of pain relief. Springer-Verlag Berlin Heidelberg, 2000 Key words Buffered ketoprofen nationallicence Ibuprofen nationallicence Third molar surgery nationallicence Seymour R. A. Department of Restorative Dentistry, The Dental School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4BW, UK e-mail: r.a.seymour@newcastle./ac.uk Tel.: +44-191-2227825; Fax: +44-191-2226137, GB aut Watkinson H. Department of Oral and Maxillofacial Surgery, Newcastle General Hospital, Newcastle upon Tyne, Newcastle, UK, GB aut Hawkesford J. E. Department of Oral and Maxillofacial Surgery, Newcastle General Hospital, Newcastle upon Tyne, Newcastle, UK, GB aut Moore U. Department of Oral and Maxillofacial Surgery, University of Newcastle upon Tyne, Newcastle, UK, GB aut https://doi.org/10.1007/s002280050700 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050700 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seymour R. A. Department of Restorative Dentistry, The Dental School, Framlington Place, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4BW, UK e-mail: r.a.seymour@newcastle./ac.uk Tel.: +44-191-2227825; Fax: +44-191-2226137, GB aut NATIONALLICENCE 700 1- Watkinson H. Department of Oral and Maxillofacial Surgery, Newcastle General Hospital, Newcastle upon Tyne, Newcastle, UK, GB aut NATIONALLICENCE 700 1- Hawkesford J. E. Department of Oral and Maxillofacial Surgery, Newcastle General Hospital, Newcastle upon Tyne, Newcastle, UK, GB aut NATIONALLICENCE 700 1- Moore U. Department of Oral and Maxillofacial Surgery, University of Newcastle upon Tyne, Newcastle, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer