caa a22 4500 475818032 CHVBK 20180406123814.0 cr unu---uuuuu 170329e20000301xx s 000 0 eng 10.1007/s002280050698 doi (NATIONALLICENCE)springer-10.1007/s002280050698 Probucol reduces lysophosphatidylcholines in low-density lipoprotein [Elektronische Daten] [M. Yoshinari, A. -H. Shi, H. Yoshizumi, M. Wakisaka, M. Iwase, M. Fujishima] Objectives: Lysophosphatidylcholine (LPC) in low-density lipoprotein (LDL) comes into notice as an important atherogenic substance. Methods: Since the effect of probucol, an antioxidative lipid-lowering drug, on LPC molecular species has not been elucidated, two LPC molecular species, stearoyl LPC (SLPC) and palmitoyl LPC (PLPC), were measured in LDL using high-pressure liquid chromatography. LDL was obtained from 11 hyperlipidemic patients, including 9 diabetic patients, in comparison with 11 age- and gender-matched controls. Results and conclusion: Hyperlipidemic patients showed nearly twofold higher levels of SLPC and PLPC per gram of LDL protein than those of controls. All hyperlipidemic patients were treated with oral administration of 500 mg/day of probucol for 3 months. Both LPCs in LDL were significantly reduced to control levels and were increased again up to the pretreatment levels 4 weeks after cessation of the treatment. Therefore, probucol has a potent effect in reducing LPC and may contribute to decreasing the atherogenicity of LDL. Springer-Verlag Berlin Heidelberg, 2000 Key words Probucol nationallicence Lysophosphatidylcholine nationallicence Low-density lipoprotein nationallicence Yoshinari M. Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582 Japan e-mail: yosinari@intmed2.med.kyushu-u.ac.jp Tel.: +81-92-6425256; Fax: +81-92-6425271, JP aut Shi A. -H Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582 Japan e-mail: yosinari@intmed2.med.kyushu-u.ac.jp Tel.: +81-92-6425256; Fax: +81-92-6425271, JP aut Yoshizumi H. Department of Internal Medicine, National Kyushu Medical Center Hospital, Fukuoka, Japan, JP aut Wakisaka M. Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582 Japan e-mail: yosinari@intmed2.med.kyushu-u.ac.jp Tel.: +81-92-6425256; Fax: +81-92-6425271, JP aut Iwase M. Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582 Japan e-mail: yosinari@intmed2.med.kyushu-u.ac.jp Tel.: +81-92-6425256; Fax: +81-92-6425271, JP aut Fujishima M. Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582 Japan e-mail: yosinari@intmed2.med.kyushu-u.ac.jp Tel.: +81-92-6425256; Fax: +81-92-6425271, JP aut https://doi.org/10.1007/s002280050698 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050698 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshinari M. Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582 Japan e-mail: yosinari@intmed2.med.kyushu-u.ac.jp Tel.: +81-92-6425256; Fax: +81-92-6425271, JP aut NATIONALLICENCE 700 1- Shi A. -H Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582 Japan e-mail: yosinari@intmed2.med.kyushu-u.ac.jp Tel.: +81-92-6425256; Fax: +81-92-6425271, JP aut NATIONALLICENCE 700 1- Yoshizumi H. Department of Internal Medicine, National Kyushu Medical Center Hospital, Fukuoka, Japan, JP aut NATIONALLICENCE 700 1- Wakisaka M. Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582 Japan e-mail: yosinari@intmed2.med.kyushu-u.ac.jp Tel.: +81-92-6425256; Fax: +81-92-6425271, JP aut NATIONALLICENCE 700 1- Iwase M. Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582 Japan e-mail: yosinari@intmed2.med.kyushu-u.ac.jp Tel.: +81-92-6425256; Fax: +81-92-6425271, JP aut NATIONALLICENCE 700 1- Fujishima M. Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582 Japan e-mail: yosinari@intmed2.med.kyushu-u.ac.jp Tel.: +81-92-6425256; Fax: +81-92-6425271, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer