caa a22 4500 475818229 CHVBK 20180406123815.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1007/s002280050721 doi (NATIONALLICENCE)springer-10.1007/s002280050721 Multiple-dose pharmacokinetics of cefepime in long-term hemodialysis with high-flux membranes [Elektronische Daten] [S. Schmaldienst, F. Traunmüller, H. Burgmann, A. R. Rosenkranz, R. Thalhammer-Scherrer, W. H. Hörl, F. Thalhammer] Objective: Among uremic patients on hemodialysis, infectious complications leading to a high incidence of morbidity and mortality are a well-documented problem. In this multi-dose study, the safety, tolerance, and pharmacokinetics of cefepime during high-flux hemodialysis were investigated and an improved dosing schedule is presented. Methods: Six long-term hemodialysis patients received 2 g cefepime i.v. at the end of hemodialysis three times per week. Results: Trough levels of cefepime were 23.3 ± 7.3 mg/l and peak serum concentrations 165.6 ± 48.7 mg/l. After 3.5 h of high-flux hemodialysis, 72.2 ± 6.4% of cefepime was eliminated. The intradialytic half-life was 1.6 ± 0.29 h and the interdialytic half-life 22.0 ± 2.14 h. Conclusion: A dosage of 2 g cefepime after each hemodialysis session achieved drug levels well above the minimal inhibitory concentration (MIC)90 for most of the target pathogens. Thus, the described dosing schedule is an efficient and cost saving antmicrobial therapy for severe infections in long-term hemodialysis patients with no residual renal function. Springer-Verlag Berlin Heidelberg, 2000 Key words Cefepime nationallicence Hemodialysis nationallicence Pharmacokinetics nationallicence Pharmacodynamic nationallicence Schmaldienst S. Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria, AT aut Traunmüller F. Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria e-mail: florian.thalhammer@akh-wien.ac.at Tel.: +43-1-404004440; Fax: +49-89-2443-18696, AT aut Burgmann H. Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria e-mail: florian.thalhammer@akh-wien.ac.at Tel.: +43-1-404004440; Fax: +49-89-2443-18696, AT aut Rosenkranz A. R. Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria, AT aut Thalhammer-Scherrer R. Department of Laboratory Medicine, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria, AT aut Hörl W. H. Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria, AT aut Thalhammer F. Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria e-mail: florian.thalhammer@akh-wien.ac.at Tel.: +43-1-404004440; Fax: +49-89-2443-18696, AT aut https://doi.org/10.1007/s002280050721 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050721 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schmaldienst S. Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria, AT aut NATIONALLICENCE 700 1- Traunmüller F. Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria e-mail: florian.thalhammer@akh-wien.ac.at Tel.: +43-1-404004440; Fax: +49-89-2443-18696, AT aut NATIONALLICENCE 700 1- Burgmann H. Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria e-mail: florian.thalhammer@akh-wien.ac.at Tel.: +43-1-404004440; Fax: +49-89-2443-18696, AT aut NATIONALLICENCE 700 1- Rosenkranz A. R. Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria, AT aut NATIONALLICENCE 700 1- Thalhammer-Scherrer R. Department of Laboratory Medicine, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria, AT aut NATIONALLICENCE 700 1- Hörl W. H. Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria, AT aut NATIONALLICENCE 700 1- Thalhammer F. Department of Internal Medicine I, Division of Infectious Diseases, University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria e-mail: florian.thalhammer@akh-wien.ac.at Tel.: +43-1-404004440; Fax: +49-89-2443-18696, AT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer