caa a22 4500 475818393 CHVBK 20180406123815.0 cr unu---uuuuu 170329e20000601xx s 000 0 eng 10.1007/s002280000144 doi (NATIONALLICENCE)springer-10.1007/s002280000144 Deviations from evidence-based prescribing of non-steroidal anti-inflammatory drugs in three European regions [Elektronische Daten] [U. Bergman, M. Andersen, A. Vaccheri, L. Bjerrum, B. Wettermark, N. Montanaro] Objective: We examined to what extent the evidence of the relative gastrointestinal toxicity with non-steroidal anti-inflammatory drugs (NSAIDs) was implemented in clinical practice in Bologna, Italy, Funen, Denmark, and Stockholm, Sweden, areas with accurate computerised information on prescriptions purchased by defined populations. Methods: We ranked each NSAID by purchased volume in defined daily doses during September 1996 and compared it with the ranking of gastrointestinal complications from a meta-analysis of controlled epidemiological studies published between 1986 and 1994. We restricted our comparison to those NSAIDs that accounted for 90% of the use and within this DU90% segment we determined the proportion of "high risk” (azapropazone, ketoprofen, piroxicam) and "low risk” (ibuprofen, diclofenac) drugs with respect to gastrointestinal toxicity. Results: In Funen, Denmark, we found the best NSAID profile (63% low risk/11% high risk) while Bologna, Italy, had the other extreme (26% low risk/38% high risk), with Stockholm, Sweden, in between (43% low risk/20% high risk). Conclusion: Our study suggests that factors other than evidence-based medicine had a dominating impact on the use of prescription NSAIDs in 1996. Springer-Verlag Berlin Heidelberg, 2000 Key words Anti-inflammatory agents nationallicence Non-steroidal nationallicence Drug utilisation nationallicence Bergman U. Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, SE-14186 Stockholm, Sweden e-mail: Ulf.Bergman@pharmlab.hs.sll.se Tel.: +46-8-58581196; Fax: +46-8-58581070, SE aut Andersen M. Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense University, Odense, Denmark, DK aut Vaccheri A. Interuniversity Research Centre for Pharmacoepidemiology, Department of Pharmacology, University of Bologna, Bologna, Italy, IT aut Bjerrum L. Research Unit of General Practice and Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense University, Odense, Denmark, DK aut Wettermark B. Department of Pharmacy, Huddinge University Hospital, Huddinge, Sweden, SE aut Montanaro N. Interuniversity Research Centre for Pharmacoepidemiology, Department of Pharmacology, University of Bologna, Bologna, Italy, IT aut https://doi.org/10.1007/s002280000144 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280000144 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bergman U. Division of Clinical Pharmacology, Karolinska Institutet, Huddinge University Hospital, SE-14186 Stockholm, Sweden e-mail: Ulf.Bergman@pharmlab.hs.sll.se Tel.: +46-8-58581196; Fax: +46-8-58581070, SE aut NATIONALLICENCE 700 1- Andersen M. Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense University, Odense, Denmark, DK aut NATIONALLICENCE 700 1- Vaccheri A. Interuniversity Research Centre for Pharmacoepidemiology, Department of Pharmacology, University of Bologna, Bologna, Italy, IT aut NATIONALLICENCE 700 1- Bjerrum L. Research Unit of General Practice and Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense University, Odense, Denmark, DK aut NATIONALLICENCE 700 1- Wettermark B. Department of Pharmacy, Huddinge University Hospital, Huddinge, Sweden, SE aut NATIONALLICENCE 700 1- Montanaro N. Interuniversity Research Centre for Pharmacoepidemiology, Department of Pharmacology, University of Bologna, Bologna, Italy, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer