caa a22 4500 475818423 CHVBK 20180406123815.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s002280000170 doi (NATIONALLICENCE)springer-10.1007/s002280000170 An approach for the estimation of drug prescribing using the defined daily dose methodology and drug dispensation data [Elektronische Daten] Theoretical considerations and practical applications [M. Cosentino, O. Leoni, F. Banfi, S. Lecchini, G. Frigo] Objective: To test the hypothesis that comparison of defined daily dose (DDD) and drug user data may help to estimate drug exposure in a defined population and provide information about drug prescribing patterns. Methods and results: First, comparison of DDD figures with the number of apparent drug users (ADU, i.e., individuals for whom at least one prescription of the drug had been dispensed during a given time period) is demonstrated to correspond to the product of the prescribed daily dose (PDD) and the proportion of days in which the drug had been taken (days of treatment/days in a time period, D). The resulting equation (DDD/day)/ADU in a time period=PDD × D is then applied to the analysis of different sets of drug dispensation data. Examples show that this approach may be helpful to monitor drug prescribing patterns over time. Moreover, in definite situations, it may provide reliable estimates of either PDD or D. Conclusions: Comparison of DDD and drug user data is suggested to be a cost-effective strategy to monitor drug prescribing patterns from an epidemiological perspective, which may be useful to researchers involved in drug utilisation studies as well as to health authorities for monitoring and regulatory purposes. Springer-Verlag Berlin Heidelberg, 2000 Key words Drug prescribing nationallicence Defined daily dose nationallicence Drug dispensation data nationallicence Cosentino M. Department of Internal Medicine and Therapeutics, Section of Clinical Pharmacology, University of Insubria and University of Pavia, Via Ottorino Rossi n. 9, I-21100 Varese VA, Italy e-mail: phrm2fmc@unipv.it Tel.: +39-0332-811601; Fax: +39-0332-811601, IT aut Leoni O. Department of Internal Medicine and Therapeutics, Section of Clinical Pharmacology, University of Insubria and University of Pavia, Via Ottorino Rossi n. 9, I-21100 Varese VA, Italy e-mail: phrm2fmc@unipv.it Tel.: +39-0332-811601; Fax: +39-0332-811601, IT aut Banfi F. Area Health Authority of Varese, Italy, IT aut Lecchini S. Department of Internal Medicine and Therapeutics, Section of Clinical Pharmacology, University of Insubria and University of Pavia, Via Ottorino Rossi n. 9, I-21100 Varese VA, Italy e-mail: phrm2fmc@unipv.it Tel.: +39-0332-811601; Fax: +39-0332-811601, IT aut Frigo G. Department of Internal Medicine and Therapeutics, Section of Clinical Pharmacology, University of Insubria and University of Pavia, Via Ottorino Rossi n. 9, I-21100 Varese VA, Italy e-mail: phrm2fmc@unipv.it Tel.: +39-0332-811601; Fax: +39-0332-811601, IT aut https://doi.org/10.1007/s002280000170 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280000170 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cosentino M. Department of Internal Medicine and Therapeutics, Section of Clinical Pharmacology, University of Insubria and University of Pavia, Via Ottorino Rossi n. 9, I-21100 Varese VA, Italy e-mail: phrm2fmc@unipv.it Tel.: +39-0332-811601; Fax: +39-0332-811601, IT aut NATIONALLICENCE 700 1- Leoni O. Department of Internal Medicine and Therapeutics, Section of Clinical Pharmacology, University of Insubria and University of Pavia, Via Ottorino Rossi n. 9, I-21100 Varese VA, Italy e-mail: phrm2fmc@unipv.it Tel.: +39-0332-811601; Fax: +39-0332-811601, IT aut NATIONALLICENCE 700 1- Banfi F. Area Health Authority of Varese, Italy, IT aut NATIONALLICENCE 700 1- Lecchini S. Department of Internal Medicine and Therapeutics, Section of Clinical Pharmacology, University of Insubria and University of Pavia, Via Ottorino Rossi n. 9, I-21100 Varese VA, Italy e-mail: phrm2fmc@unipv.it Tel.: +39-0332-811601; Fax: +39-0332-811601, IT aut NATIONALLICENCE 700 1- Frigo G. Department of Internal Medicine and Therapeutics, Section of Clinical Pharmacology, University of Insubria and University of Pavia, Via Ottorino Rossi n. 9, I-21100 Varese VA, Italy e-mail: phrm2fmc@unipv.it Tel.: +39-0332-811601; Fax: +39-0332-811601, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer