caa a22 4500 475818520 CHVBK 20180406123816.0 cr unu---uuuuu 170329e20000901xx s 000 0 eng 10.1007/s002280000177 doi (NATIONALLICENCE)springer-10.1007/s002280000177 An investigation into the efficacy of intravenous diclofenac in post-operative dental pain [Elektronische Daten] [R. A. Seymour, U. Moore, J. Hawkesford, P. Coulthard, D. Jackson-Leech, D. Thomas, M. Hill, M. L. Combs, T. Renton, M. McGurk] Objective: To evaluate the efficacy of single doses of intravenous diclofenac sodium (25, 50 and 75 mg) in patients with post-operative pain after third-molar surgery in a randomised, placebo-controlled study. Methods: Two hundred and sixty-nine patients (168 females) who required the removal of their impacted third molars participated in the study, which had received prior ethical approval. Surgery was completed under general anaesthesia and, during the early post-operative period, patients received either a single intravenous dose of diclofenac (25, 50 or 75 mg) or matched placebo in random, double-blind order. Pain intensity was assessed on 10-cm visual analogue scales at fixed time points throughout a 4-h investigation period. Other efficacy variables obtained included time until rescue medication and overall assessment at 4, 6, 12 and 24 h after dosing. Results: Throughout the 4-h investigation period, patients treated with diclofenac reported significantly less pain than those treated with placebo (P < 0.001). No differences were observed among the three doses of diclofenac (P=0.22). Similar results were observed at 6, 12 and 24 h after dosing. Significant differences were also noted between the placebo group and all the diclofenac treatment groups with respect to time until rescue medication (P < 0.001) and the proportion of patients taking such medication. Conclusion: Single doses of i.v. diclofenac (25, 50 and 75 mg) provide significant pain relief after third-molar surgery. The efficacy of this preparation does not appear to be dose related. Springer-Verlag Berlin Heidelberg, 2000 Key words Diclofenac sodium nationallicence Post-operative pain nationallicence Third-molar surgery nationallicence Seymour R. A. Department of Restorative Dentistry, Dental School, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK e-mail: r.a.seymour@newcastle.ac.uk Tel.: +44-191-2227825; Fax: +44-191-2226137, GB aut Moore U. Department of Oral Surgery, University of Newcastle upon Tyne, UK, GB aut Hawkesford J. Department of Oral Surgery, University of Newcastle upon Tyne, UK, GB aut Coulthard P. Department of Oral Surgery, Manchester Dental School, Manchester, UK, GB aut Jackson-Leech D. Department of Oral Surgery, Manchester Dental School, Manchester, UK, GB aut Thomas D. Department of Oral Surgery, Cardiff Dental School, Cardiff, UK, GB aut Hill M. Department of Oral Surgery, Cardiff Dental School, Cardiff, UK, GB aut Combs M. L. MDS Harris, Lincoln, Nebraska, USA, US aut Renton T. Department of Oral Surgery, Cardiff Dental School, Cardiff, UK, GB aut McGurk M. Department of Oral Surgery, GKT, London, UK, GB aut https://doi.org/10.1007/s002280000177 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280000177 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seymour R. A. Department of Restorative Dentistry, Dental School, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK e-mail: r.a.seymour@newcastle.ac.uk Tel.: +44-191-2227825; Fax: +44-191-2226137, GB aut NATIONALLICENCE 700 1- Moore U. Department of Oral Surgery, University of Newcastle upon Tyne, UK, GB aut NATIONALLICENCE 700 1- Hawkesford J. Department of Oral Surgery, University of Newcastle upon Tyne, UK, GB aut NATIONALLICENCE 700 1- Coulthard P. Department of Oral Surgery, Manchester Dental School, Manchester, UK, GB aut NATIONALLICENCE 700 1- Jackson-Leech D. Department of Oral Surgery, Manchester Dental School, Manchester, UK, GB aut NATIONALLICENCE 700 1- Thomas D. Department of Oral Surgery, Cardiff Dental School, Cardiff, UK, GB aut NATIONALLICENCE 700 1- Hill M. Department of Oral Surgery, Cardiff Dental School, Cardiff, UK, GB aut NATIONALLICENCE 700 1- Combs M. L. MDS Harris, Lincoln, Nebraska, USA, US aut NATIONALLICENCE 700 1- Renton T. Department of Oral Surgery, Cardiff Dental School, Cardiff, UK, GB aut NATIONALLICENCE 700 1- McGurk M. Department of Oral Surgery, GKT, London, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer