caa a22 4500 475818539 CHVBK 20180406123816.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s002280000136 doi (NATIONALLICENCE)springer-10.1007/s002280000136 The relationship between risk of hypoglycemia and use of cibenzoline and disopyramide [Elektronische Daten] [M. Takada, S. Fujita, Y. Katayama, Y. Harano, M. Shibakawa] Objective: A case-control study was carried out to compare the risks of hypoglycemia caused by disopyramide and cibenzoline. Methods: We selected 91 subjects with hypoglycemia from among 14,156 outpatients who consulted the National Cardiovascular Center (NCVC) and received drug therapy between September 1997 and February 1998. We used the fasting blood sugar (FBS) level of 75 mg/dl or less as the cut-off level to screen for hypoglycemia. For each case, five controls matched for gender and age were selected from the clinical division consulted by relevant subjects. Results: Ninety-one cases and 455 controls were enrolled in this study. Of 91 cases with hypoglycemia, 8 (8.8%) were treated with cibenzoline and 3 (3.3%) with disopyramide. The percentage of cases treated with cibenzoline was greater than that in the controls (1.5%), and the prescription frequency of cibenzoline during the study period was 2%. With adjustment for potential confounding factors using conditional logistic regression, hypoglycemia was significantly correlated with the use of cibenzoline [OR 8.0 (95% CI 1.7-36.8)], insulin [OR 48.4 (95% CI 8.8-267.2)], and thyroid agents [OR 13.0 (95% CI 1.1-160.4)]. An increased risk of hypoglycemia associated with the use of sulfonylureas was not detected. In additional logistic regression analysis, including the variables with individual sulfonylureas, glibenclamide but not gliclazide significantly increased the risk of hypoglycemia. The use of disopyramide did not affect the risk of hypoglycemia. In separate analyses for diabetic and non-diabetic patients, the risks of hypoglycemia associated with the use of drugs other than β-blocking agents in non-diabetic patients were estimated to be lower than those in diabetic patients. Conclusion: The use of cibenzoline was significantly correlated with an increased risk of hypoglycemia. Springer-Verlag Berlin Heidelberg, 2000 Key words Hypoglycemia nationallicence ATP-sensitive K+ channel nationallicence Cibenzoline nationallicence Takada M. Department of Pharmacy, National Cardiovascular Center, 5-7-1, Fujishirodai, Suita-city, Osaka 565-0873, Japan e-mail: takadam@ncvc.hosp.go.jp Tel.: +81-6-68335012; Fax: +81-6-68339865, JP aut Fujita S. Laboratory of Clinical Chemistry, National Cardiovascular Center, 5-7-1, Fujishirodai, Suita-city, Osaka 565-0873, Japan, JP aut Katayama Y. Laboratory of Clinical Chemistry, National Cardiovascular Center, 5-7-1, Fujishirodai, Suita-city, Osaka 565-0873, Japan, JP aut Harano Y. Division of Atherosclerosis, Metabolism, and Clinical Nutrition, Department of Medicine, National Cardiovascular Center, 5-7-1, Fujishirodai, Suita-city, Osaka 565-0873, Japan, JP aut Shibakawa M. Department of Pharmacy, National Cardiovascular Center, 5-7-1, Fujishirodai, Suita-city, Osaka 565-0873, Japan e-mail: takadam@ncvc.hosp.go.jp Tel.: +81-6-68335012; Fax: +81-6-68339865, JP aut https://doi.org/10.1007/s002280000136 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280000136 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takada M. Department of Pharmacy, National Cardiovascular Center, 5-7-1, Fujishirodai, Suita-city, Osaka 565-0873, Japan e-mail: takadam@ncvc.hosp.go.jp Tel.: +81-6-68335012; Fax: +81-6-68339865, JP aut NATIONALLICENCE 700 1- Fujita S. Laboratory of Clinical Chemistry, National Cardiovascular Center, 5-7-1, Fujishirodai, Suita-city, Osaka 565-0873, Japan, JP aut NATIONALLICENCE 700 1- Katayama Y. Laboratory of Clinical Chemistry, National Cardiovascular Center, 5-7-1, Fujishirodai, Suita-city, Osaka 565-0873, Japan, JP aut NATIONALLICENCE 700 1- Harano Y. Division of Atherosclerosis, Metabolism, and Clinical Nutrition, Department of Medicine, National Cardiovascular Center, 5-7-1, Fujishirodai, Suita-city, Osaka 565-0873, Japan, JP aut NATIONALLICENCE 700 1- Shibakawa M. Department of Pharmacy, National Cardiovascular Center, 5-7-1, Fujishirodai, Suita-city, Osaka 565-0873, Japan e-mail: takadam@ncvc.hosp.go.jp Tel.: +81-6-68335012; Fax: +81-6-68339865, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer