caa a22 4500 475818598 CHVBK 20180406123816.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s002280000130 doi (NATIONALLICENCE)springer-10.1007/s002280000130 Cyclical etidronate use is not associated with symptoms of peptic ulcer disease [Elektronische Daten] [H. Burger, R. M. C. Herings, A. C. G. Egberts, C. Neef, H. G. M. Leufkens] Objective: To investigate whether the alkylbisphosphonate etidronate is associated with an increased risk of gastrointestinal symptoms. Methods: We conducted an observational follow-up study on a possible relationship between etidronate use and the risk of gastrointestinal symptoms in a cohort of 2754 women over 50 years of age. The study was performed with data on drug prescriptions obtained from the PHARMO database in the Netherlands. Women were included when they used either cyclical etidronate (n=1050) or estrogen (n=1704) for at least 14 days. They were followed-up for incident use of antiulcer drugs while on exposure medication. Results: The mean ages were 72 years and 59 years in the etidronate and estrogen groups, respectively. In total, there were 95 women with incident prescriptions for gastrointestinal events after a median duration of follow-up of 2.7 months (range 0.1-19.4 months). The crude relative risk of a gastrointestinal event for etidronate compared with estrogen use was 1.2 [95% confidence interval (95% CI) 0.8-1.8]. Adjusted for baseline age, use of corticosteroids, salicylates and nonsteroidal anti-inflammatory drugs, the relative risk reversed to 0.6 (95% CI 0.4-1.2). Conclusion: The use of cyclical etidronate is not associated with an elevated risk of symptoms of peptic ulcer disease. Springer-Verlag Berlin Heidelberg, 2000 Key words Osteoporosis nationallicence Treatment nationallicence Bisphosphonates nationallicence Burger H. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands, NL aut Herings R. M. C. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands, NL aut Egberts A. C. G. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands, NL aut Neef C. Medicines Evaluation Board, The Hague, The Netherlands, NL aut Leufkens H. G. M. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands, NL aut https://doi.org/10.1007/s002280000130 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280000130 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Burger H. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands, NL aut NATIONALLICENCE 700 1- Herings R. M. C. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands, NL aut NATIONALLICENCE 700 1- Egberts A. C. G. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands, NL aut NATIONALLICENCE 700 1- Neef C. Medicines Evaluation Board, The Hague, The Netherlands, NL aut NATIONALLICENCE 700 1- Leufkens H. G. M. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, The Netherlands, NL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer