caa a22 4500 475818768 CHVBK 20180406123816.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1007/s002280000186 doi (NATIONALLICENCE)springer-10.1007/s002280000186 Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness [Elektronische Daten] [G.H. Kamimori, D.M. Penetar, D.B. Headley, D.R. Thorne, R. Otterstetter, G. Belenky] Abstract.: Objective: Determine the relationship between caffeine, catecholamines, and alertness during prolonged wakefulness. Methods: Following 49h of prolonged wakefulness, each of 50 healthy males (18-32years) orally ingested either a placebo or one of three doses of caffeine, 2.1 (low), 4.3 (medium), or 8.6mg kg-1 body weight (high), in a randomized double-blind design. Wakefulness continued for an additional 12h during which venous blood samples were collected for catecholamine and caffeine analysis [determined using high-performance liquid chromatography (HPLC)]. A sleep latency test, the Stanford sleepiness scale, and a choice reaction time test were administered periodically during the post-dosing period and served as measures of alertness (physiological, subjective, and behavioral, respectively). Results: Caffeine had no significant effect on noradrenaline, but adrenaline was significantly increased between 1h and 4h post-dosing in the high dose group compared with a placebo group. Following caffeine administration, responses to sleep latency, sleepiness scores, and reaction time scores showed dose-related changes that were exhibited by significant correlation coefficients. Conclusion: The results indicate that high doses of caffeine have a significant and beneficial effect on alertness during prolonged wakefulness. Springer-Verlag, 2000 Caffeine Catecholamines Sleep latency nationallicence Kamimori G.H. Department of Neurobiology and Behavior, Division of Neuropsychiatry, Walter Reed Army Institute of Research, 20307-5100, Washington, DC, USA aut Penetar D.M. U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA aut Headley D.B. Department of Neurobiology and Behavior, Division of Neuropsychiatry, Walter Reed Army Institute of Research, 20307-5100, Washington, DC, USA aut Thorne D.R. Department of Neurobiology and Behavior, Division of Neuropsychiatry, Walter Reed Army Institute of Research, 20307-5100, Washington, DC, USA aut Otterstetter R. Department of Neurobiology and Behavior, Division of Neuropsychiatry, Walter Reed Army Institute of Research, 20307-5100, Washington, DC, USA aut Belenky G. Department of Neurobiology and Behavior, Division of Neuropsychiatry, Walter Reed Army Institute of Research, 20307-5100, Washington, DC, USA aut European Journal of Clinical Pharmacology Springer-Verlag 56/8(2000-11-01), 537-544 0031-6970 56:8<537 2000 56 228 https://doi.org/10.1007/s002280000186 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280000186 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kamimori G.H. Department of Neurobiology and Behavior, Division of Neuropsychiatry, Walter Reed Army Institute of Research, 20307-5100, Washington, DC, USA aut NATIONALLICENCE 700 1- Penetar D.M. U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA aut NATIONALLICENCE 700 1- Headley D.B. Department of Neurobiology and Behavior, Division of Neuropsychiatry, Walter Reed Army Institute of Research, 20307-5100, Washington, DC, USA aut NATIONALLICENCE 700 1- Thorne D.R. Department of Neurobiology and Behavior, Division of Neuropsychiatry, Walter Reed Army Institute of Research, 20307-5100, Washington, DC, USA aut NATIONALLICENCE 700 1- Otterstetter R. Department of Neurobiology and Behavior, Division of Neuropsychiatry, Walter Reed Army Institute of Research, 20307-5100, Washington, DC, USA aut NATIONALLICENCE 700 1- Belenky G. Department of Neurobiology and Behavior, Division of Neuropsychiatry, Walter Reed Army Institute of Research, 20307-5100, Washington, DC, USA aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 56/8(2000-11-01), 537-544 0031-6970 56:8<537 2000 56 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer