caa a22 4500 475819225 CHVBK 20180406123818.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s002280000228 doi (NATIONALLICENCE)springer-10.1007/s002280000228 Inhibition of puerperal lactation with 2-mercaptopropionyl-glycine [Elektronische Daten] [C. Akrivis, P. Vezyraki, D.N. Kiortsis, A. Fotopoulos, A. Evangelou] Abstract.: Objectives: Thiols (sulfydryl compounds) have a prolactin-lowering effect in animals. The purpose of our study was to evaluate the effects of orally administered N-2-mercaptopropionyl-glycine (tiopronin) on suppression of lactation and plasma prolactin (PRL) levels in a group of women in the puerperium. Methods: One hundred women aged 17-37 years were studied. We divided our population in four groups (25 patients in each group). In group I, no medication was administered but only conservative measures were taken (restriction of fluid intake, ice-bags applied on the breasts, tight breast binders). Subjects in group II received tiopronin (200mg/day) for 14days. In group III, tiopronin (500mg/day) was administered for 14days. Subjects in group IV, took bromocriptine (5mg/day) for 14days. Assessment of suppression of lactation was performed clinically and laboratory determinations were obtained before and after 1, 2, 3, 4, and 14days of treatment. Furthermore, in seven healthy women plasma PRL responses to thyrotropin-releasing hormone (TRH) before and after one week of tiopronin therapy (500mg/day) were studied. Results: Statistically significant higher percentages of success of lactation suppression were obtained with tiopronin (84% and 88%) and bromocriptine (96%) compared to conservative treatment (60%). In the four groups a significant decrease of PRL was observed. However, in women who received tiopronin and bromocriptine, the levels of PRL after 14days of therapy were lower compared to the conservative treatment group. Moreover, in the tiopronin groups and the bromocriptine group, lactation was stopped earlier. In the first group (conservative measures) the lactation was suppressed after 13.3±5.4days of treatment. In the groups who received tiopronin (200mg/day and 500mg/day) lactation was suppressed after 4.4±1.7 and 4.3±1.6days of treatment. In the bromocriptine group the lactation was stopped after 1.2±0.4days. Bromocriptine treatment was associated with more frequent side effects than the tiopronin. Conclusion: Administration of tiopronin in low to moderate doses is effective in suppression of puerperal lactation. Springer-Verlag, 2000 Prolactin Tiopronin Puerperal lactation nationallicence Akrivis C. Obstetrics and Gynaecology Clinic, General Hospital of Ioannina, Ioannina, Greece aut Vezyraki P. Laboratory of Physiology, Clinical Physiology Unit, Medical Faculty, University of Ioannina, Ioannina, Greece aut Kiortsis D.N. Laboratory of Physiology, Clinical Physiology Unit, Medical Faculty, University of Ioannina, Ioannina, Greece aut Fotopoulos A. Laboratory of Nuclear Medicine, Medical Faculty, University of Ioannina, Ioannina, Greece aut Evangelou A. Laboratory of Physiology, Clinical Physiology Unit, Medical Faculty, University of Ioannina, Ioannina, Greece aut European Journal of Clinical Pharmacology Springer-Verlag 56/9-10(2000-12-01), 621-623 0031-6970 56:9-10<621 2000 56 228 https://doi.org/10.1007/s002280000228 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280000228 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Akrivis C. Obstetrics and Gynaecology Clinic, General Hospital of Ioannina, Ioannina, Greece aut NATIONALLICENCE 700 1- Vezyraki P. Laboratory of Physiology, Clinical Physiology Unit, Medical Faculty, University of Ioannina, Ioannina, Greece aut NATIONALLICENCE 700 1- Kiortsis D.N. Laboratory of Physiology, Clinical Physiology Unit, Medical Faculty, University of Ioannina, Ioannina, Greece aut NATIONALLICENCE 700 1- Fotopoulos A. Laboratory of Nuclear Medicine, Medical Faculty, University of Ioannina, Ioannina, Greece aut NATIONALLICENCE 700 1- Evangelou A. Laboratory of Physiology, Clinical Physiology Unit, Medical Faculty, University of Ioannina, Ioannina, Greece aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 56/9-10(2000-12-01), 621-623 0031-6970 56:9-10<621 2000 56 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer