caa a22 4500 475819241 CHVBK 20180406123818.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s002280000214 doi (NATIONALLICENCE)springer-10.1007/s002280000214 Effects and pharmacokinetics of oral glibenclamide and glipizide in Caucasian and Chinese patients with type-2 diabetes [Elektronische Daten] [Anders Jönsson, Juliana C.N. Chan, Tony Rydberg, Stein Vaaler, Bengt Hallengren, Clive S. Cockram, Julian A.J.H. Critchley, Arne Melander] Abstract.: The effects and kinetics of oral glibenclamide (Gb) and glipizide (Gz) were studied in Caucasian and Chinese patients (ten in each group) with type-2 diabetes. In randomised order, 2.5mg Gb, 2.5mg Gz or placebo was given orally before the administration of 75g oral glucose. Concentrations of insulin and proinsulin were determined using radioimmunoassay (RIA) without cross-reactivities, and sulphonylurea concentrations were determined using high-performance liquid chromatography (HPLC). There were no significant interethnic differences in Gb or Gz effects whether on glucose, insulin or proinsulin/insulin ratio at any time point. Following Gz, however, Chinese patients had greater increments of serum proinsulin at 10-30min compared with Caucasians. Apart from the maximum plasma concentration (Cmax) and area under the plasma concentration-time curve (AUC) of Gz being higher among the Chinese, no significant interethnic differences in pharmacokinetics were found. It appears that the same dosage principles could be used for Caucasian and Chinese patients with type-2 diabetes when Gb or Gz are prescribed. Springer-Verlag, 2000 Sulphonylurea Proinsulin Pharmacokinetics nationallicence Jönsson Anders Department of Endocrinology, Lund University, Malmö University Hospital, Malmö, Sweden aut Chan Juliana C.N. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong aut Rydberg Tony The Pharmacies in Skåne, Malmö, Sweden aut Vaaler Stein Epidemiologic Centre, Rikshospitalet, Oslo, Norway aut Hallengren Bengt Department of Endocrinology, Lund University, Malmö University Hospital, Malmö, Sweden aut Cockram Clive S. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong aut Critchley Julian A.J.H. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong aut Melander Arne The NEPI Foundation and Department of Community Medicine, Medical Research Centre, Malmö University Hospital, Malmö, Sweden aut European Journal of Clinical Pharmacology Springer-Verlag 56/9-10(2000-12-01), 711-714 0031-6970 56:9-10<711 2000 56 228 https://doi.org/10.1007/s002280000214 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280000214 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jönsson Anders Department of Endocrinology, Lund University, Malmö University Hospital, Malmö, Sweden aut NATIONALLICENCE 700 1- Chan Juliana C.N. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong aut NATIONALLICENCE 700 1- Rydberg Tony The Pharmacies in Skåne, Malmö, Sweden aut NATIONALLICENCE 700 1- Vaaler Stein Epidemiologic Centre, Rikshospitalet, Oslo, Norway aut NATIONALLICENCE 700 1- Hallengren Bengt Department of Endocrinology, Lund University, Malmö University Hospital, Malmö, Sweden aut NATIONALLICENCE 700 1- Cockram Clive S. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong aut NATIONALLICENCE 700 1- Critchley Julian A.J.H. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong aut NATIONALLICENCE 700 1- Melander Arne The NEPI Foundation and Department of Community Medicine, Medical Research Centre, Malmö University Hospital, Malmö, Sweden aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 56/9-10(2000-12-01), 711-714 0031-6970 56:9-10<711 2000 56 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer