caa a22 4500 475819314 CHVBK 20180406123818.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1007/s002280000215 doi (NATIONALLICENCE)springer-10.1007/s002280000215 Detecting drug-drug interactions using a database for spontaneous adverse drug reactions: an example with diuretics and non-steroidal anti-inflammatory drugs [Elektronische Daten] [Eugène P. van Puijenbroek, Antoine C.G. Egberts, Eibert R. Heerdink, Hubert G.M. Leufkens] Abstract.: Objective: Drug-drug interactions are relatively rarely reported to spontaneous reporting systems (SRSs) for adverse drug reactions. For this reason, the traditional approach for analysing SRS has major limitations for the detection of drug-drug interactions. We developed a method that may enable signalling of these possible interactions, which are often not explicitly reported, utilising reports of adverse drug reactions in data sets of SRS. As an example, the influence of concomitant use of diuretics and non-steroidal anti-inflammatory drugs (NSAIDs) on symptoms indicating a decreased efficacy of diuretics was examined using reports received by the Netherlands Pharmacovigilance Foundation Lareb. Methods: Reports received between 1 January 1990 and 1 January 1999 of patients older than 50years were included in the study. Cases were defined as reports with symptoms indicating a decreased efficacy of diuretics, non-cases as all other reports. Exposure categories were the use of NSAIDs or diuretics versus the use of neither of these drugs. The influence of the combined use of both drugs was examined using logistic regression analysis. Results: The odds ratio of the statistical interaction term of the combined use of both drugs was increased [adjusted odds ratio 2.0, 95% confidence interval (CI) 1.1-3.7], which may indicate an enhanced effect of concomitant drug use. Conclusion: The findings illustrate that spontaneous reporting systems have a potential for signal detection and the analysis of possible drug-drug interactions. The method described may enable a more active approach in the detection of drug-drug interactions after marketing. Springer-Verlag, 2000 Drug-drug interaction Pharmacovigilance Spontaneous reporting system nationallicence van Puijenbroek Eugène P. Netherlands Pharmacovigilance Foundation Lareb, Goudsbloemvallei 7, 5237 MH 's-Hertogenbosch, the Netherlands aut Egberts Antoine C.G. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, the Netherlands aut Heerdink Eibert R. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, the Netherlands aut Leufkens Hubert G.M. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, the Netherlands aut European Journal of Clinical Pharmacology Springer-Verlag 56/9-10(2000-12-01), 733-738 0031-6970 56:9-10<733 2000 56 228 https://doi.org/10.1007/s002280000215 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280000215 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Puijenbroek Eugène P. Netherlands Pharmacovigilance Foundation Lareb, Goudsbloemvallei 7, 5237 MH 's-Hertogenbosch, the Netherlands aut NATIONALLICENCE 700 1- Egberts Antoine C.G. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, the Netherlands aut NATIONALLICENCE 700 1- Heerdink Eibert R. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, the Netherlands aut NATIONALLICENCE 700 1- Leufkens Hubert G.M. Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht, the Netherlands aut NATIONALLICENCE 773 0- European Journal of Clinical Pharmacology Springer-Verlag 56/9-10(2000-12-01), 733-738 0031-6970 56:9-10<733 2000 56 228 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer