caa a22 4500 475823729 CHVBK 20180406123825.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1023/A:1018652429633 doi (NATIONALLICENCE)springer-10.1023/A:1018652429633 Incidence of Factor V Leiden in Patients with Acute Myocardial Infarction [Elektronische Daten] [Manohar Gowda, Marjorie Zucker, James Vacek, William Carriger, Dana Van Laeys, Jane Rachel, Barbara Strope] The genetic defect of coagulation factor V known as factor V Leiden produces a resistance to degradation by activated protein C (APC) and increases the risk of venous thromboembolism. The data on arterial thrombosis associated with APC resistance are still not clearly defined. We conducted a study in patients presenting with acute myocardial infarction (MI) to assess whether factor V Leiden increases the risk of arterial thrombosis. We studied 109 patients who had a diagnosis of acute MI (69 males and 40 females, aged 25-91 years), and 112 controls. The study population was identified by characteristic ECG changes and elevation of serum CK-MB, whereas the control subjects were anonymous healthy blood donors with no known history of coronary artery disease. Blood samples from the patients and controls were analyzed for the factor V Leiden mutation by DNA analysis, using the polymerase chain reaction. Heterozygous factor V Leiden mutation was found in 9 of 109 (8%) MI patients and 5 of 112 (4%) control subjects (P = .42). In conclusion, this study shows no evidence of an association between factor V Leiden and acute MI. Kluwer Academic Publishers, 2000 activated protein C resistance nationallicence factor V Leiden nationallicence myocardial infarction nationallicence thrombosis nationallicence Gowda Manohar University of Missouri, Kansas City aut Zucker Marjorie University of Missouri, Kansas City aut Vacek James University of Missouri, Kansas City aut Carriger William University of Missouri, Kansas City aut Van Laeys Dana University of Missouri, Kansas City aut Rachel Jane University of Missouri, Kansas City aut Strope Barbara University of Missouri, Kansas City aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/1(2000-01-01), 43-45 0929-5305 9:1<43 2000 9 11239 https://doi.org/10.1023/A:1018652429633 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018652429633 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gowda Manohar University of Missouri, Kansas City aut NATIONALLICENCE 700 1- Zucker Marjorie University of Missouri, Kansas City aut NATIONALLICENCE 700 1- Vacek James University of Missouri, Kansas City aut NATIONALLICENCE 700 1- Carriger William University of Missouri, Kansas City aut NATIONALLICENCE 700 1- Van Laeys Dana University of Missouri, Kansas City aut NATIONALLICENCE 700 1- Rachel Jane University of Missouri, Kansas City aut NATIONALLICENCE 700 1- Strope Barbara University of Missouri, Kansas City aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/1(2000-01-01), 43-45 0929-5305 9:1<43 2000 9 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer