caa a22 4500 475823753 CHVBK 20180406123825.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1023/A:1018656530541 doi (NATIONALLICENCE)springer-10.1023/A:1018656530541 Soluble E-Selectin is Not a Marker of Unstable Coronary Plaque in Serum of Patients with Ischemic Heart Disease [Elektronische Daten] [Marcello Galvani, Donatella Ferrini, Filippo Ottani, Cristina Nanni, Alessandro Ramberti, Paolo Amboni, Laura Iamele, Arialdo Vernocchi, Francesca Nicolini] Increased level of soluble cell adhesion molecules may be a marker for atherosclerosis and/or reflect complication of the atherosclerotic plaque. To test whether expression of cell adhesion molecules is more pronounced in unstable versus stable coronary plaques, we measured the serum level of soluble E-selectin (sE-selectin) in 99 consecutive patients admitted to the hospital for acute coronary syndromes (ACS) and in 61 patients with chronic coronary artery disease (CAD) using a commercially available ELISA kit. We also measured the sE-selectin concentration in 20 sex- and age-matched subjects without clinical evidence of atherosclerosis, who served as controls. The mean sE-selectin level was higher in both groups of patients compared with controls (ACS, 35.0 ± 23.4 ng/mL; chronic CAD, 32.9 ± 21.0 ng/mL; controls, 14.5 ± 6.6 ng/mL; one-way ANOVA, P = 0.001), but there was no difference between patients with ACS and chronic CAD. Furthermore, there was a trend (P = 0.08) toward a decrease in sE-selectin with an increase in the extent and severity of CAD. In patients with ACS, the in-hospital cardiac event rate was 8%. Although mean sE-selectin concentration tended to be higher in patients with (49.2 ± 42.1 ng/mL) than in those without (33.8 ± 21.3 ng/mL) in-hospital cardiac events, the difference was not significant. In 53 patients with ACS, C-reactive protein was measured and showed no correlation with the sE-selectin concentration. These findings show that although sE-selectin concentration is elevated in the presence of clinically relevant atherosclerosis, it does not further increase during the unstable phase of the disease, indicating that sE-selectin is not a reliable indicator of a complicated atherosclerotic plaque. Kluwer Academic Publishers, 2000 adhesion molecules nationallicence E-selectin nationallicence acute coronary syndromes nationallicence Galvani Marcello Cardiovascular Research Unit of the Fondazione Cardiologica "Myriam Zito Sacco,”, Forlì aut Ferrini Donatella Cardiovascular Research Unit of the Fondazione Cardiologica "Myriam Zito Sacco,”, Forlì aut Ottani Filippo Cardiovascular Research Unit of the Fondazione Cardiologica "Myriam Zito Sacco,”, Forlì aut Nanni Cristina Cardiovascular Research Unit of the Fondazione Cardiologica "Myriam Zito Sacco,”, Forlì aut Ramberti Alessandro Cardiovascular Research Unit of the Fondazione Cardiologica "Myriam Zito Sacco,”, Forlì aut Amboni Paolo Laboratorio di Analisi Chimico-Cliniche, Ospedali Riuniti, Bergamo aut Iamele Laura Laboratorio di Analisi Chimico-Cliniche, Ospedali Riuniti, Bergamo aut Vernocchi Arialdo Laboratorio di Analisi Chimico-Cliniche, Ospedali Riuniti, Bergamo aut Nicolini Francesca Cardiovascular Research Unit of the Fondazione Cardiologica "Myriam Zito Sacco,”, Forlì aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/1(2000-01-01), 53-60 0929-5305 9:1<53 2000 9 11239 https://doi.org/10.1023/A:1018656530541 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018656530541 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Galvani Marcello Cardiovascular Research Unit of the Fondazione Cardiologica "Myriam Zito Sacco,”, Forlì aut NATIONALLICENCE 700 1- Ferrini Donatella Cardiovascular Research Unit of the Fondazione Cardiologica "Myriam Zito Sacco,”, Forlì aut NATIONALLICENCE 700 1- Ottani Filippo Cardiovascular Research Unit of the Fondazione Cardiologica "Myriam Zito Sacco,”, Forlì aut NATIONALLICENCE 700 1- Nanni Cristina Cardiovascular Research Unit of the Fondazione Cardiologica "Myriam Zito Sacco,”, Forlì aut NATIONALLICENCE 700 1- Ramberti Alessandro Cardiovascular Research Unit of the Fondazione Cardiologica "Myriam Zito Sacco,”, Forlì aut NATIONALLICENCE 700 1- Amboni Paolo Laboratorio di Analisi Chimico-Cliniche, Ospedali Riuniti, Bergamo aut NATIONALLICENCE 700 1- Iamele Laura Laboratorio di Analisi Chimico-Cliniche, Ospedali Riuniti, Bergamo aut NATIONALLICENCE 700 1- Vernocchi Arialdo Laboratorio di Analisi Chimico-Cliniche, Ospedali Riuniti, Bergamo aut NATIONALLICENCE 700 1- Nicolini Francesca Cardiovascular Research Unit of the Fondazione Cardiologica "Myriam Zito Sacco,”, Forlì aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/1(2000-01-01), 53-60 0929-5305 9:1<53 2000 9 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer