caa a22 4500 475823907 CHVBK 20180406123826.0 cr unu---uuuuu 170329e20000101xx s 000 0 eng 10.1023/A:1018644212794 doi (NATIONALLICENCE)springer-10.1023/A:1018644212794 Effect of Short-Term Aspirin Use on C-Reactive Protein [Elektronische Daten] [DaLi Feng, Russell Tracy, Izabella Lipinska, Jaime Murillo, Carol McKenna, Geoffrey Tofler] Markers of inflammation, such as C-reactive protein (CRP) and fibrinogen, have been shown to be predictive of cardiovascular disease. In the Physicians Health Study, the magnitude of reduction in the risk of myocardial infarction with aspirin therapy was related to baseline CRP levels, raising the possibility that the protective effect of aspirin may be due to antiinflammatory properties in addition to its antiplatelet effect. We therefore investigated whether aspirin therapy lowers CRP levels. Because heavy physical exertion is a well-known trigger of myocardial infarction, we also investigated the effect of aspirin on CRP levels before and after strenuous exercise. Thirty-two healthy men, aged 29 ± 6 years, were enrolled in a randomized, double-blind, parallel study. Blood samples were obtained immediately before and after maximal treadmill exercise at baseline and following 7 days of aspirin therapy (81 or 325 mg). The levels of CRP, as measured by ELISA, increased by 13% following exercise (P < 0.0001). However, aspirin did not significantly alter CRP levels, either at rest (0.81 ± 0.13 mg/L before aspirin vs. 0.78 ± 0.13 mg/L on aspirin) or following exercise (0.92 ± 0.13 mg/L before aspirin vs. 0.86 ± 0.13 mg/L on aspirin), P = 0.73. When the resting and postexercise data were combined, the levels were 0.87 ± 0.13 mg/L before aspirin and 0.82 ± 0.13 mg/L on aspirin (a nonsignificant 6% reduction, P = 0.20). In conclusion, in healthy male subjects CRP levels were not significantly reduced by short-term aspirin therapy. Our data, taking together with other reports, suggest that aspirin may not affect the levels of inflammatory markers. However, further studies are needed with a longer duration of therapy, among subjects with coronary heart disease, and using additional markers of inflammation besides CRP to determine the long-term effects of aspirin use. Kluwer Academic Publishers, 2000 exercise nationallicence aspirin nationallicence C-reactive protein nationallicence Feng DaLi Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts aut Tracy Russell Laboratory for Clinical Biochemistry Research, University of Vermont, Colchester, Vermont, USA aut Lipinska Izabella Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts aut Murillo Jaime Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts aut McKenna Carol Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts aut Tofler Geoffrey Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/1(2000-01-01), 37-41 0929-5305 9:1<37 2000 9 11239 https://doi.org/10.1023/A:1018644212794 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018644212794 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Feng DaLi Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts aut NATIONALLICENCE 700 1- Tracy Russell Laboratory for Clinical Biochemistry Research, University of Vermont, Colchester, Vermont, USA aut NATIONALLICENCE 700 1- Lipinska Izabella Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts aut NATIONALLICENCE 700 1- Murillo Jaime Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts aut NATIONALLICENCE 700 1- McKenna Carol Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts aut NATIONALLICENCE 700 1- Tofler Geoffrey Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/1(2000-01-01), 37-41 0929-5305 9:1<37 2000 9 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer