caa a22 4500 475824008 CHVBK 20180406123826.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1023/A:1018714627681 doi (NATIONALLICENCE)springer-10.1023/A:1018714627681 Cannon Christopher Cardiovascular Division of Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts aut Bridging the Gap with New Strategies in Acute ST Elevation Myocardial Infarction: Bolus Thrombolysis, Glycoprotein IIb/IIIa Inhibitors, Combination Therapy, Percutaneous Coronary Intervention, and "Facilitated” PCI [Elektronische Daten] [Christopher Cannon] Achieving early reperfusion with thrombolytic agents or primary percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) is the cornerstone of current therapy. Two advances in pharmacologic therapy are: (1) bolus thrombolysis, which simplifies therapy, reduces door-to-needle time, and reduces the potential for medication errors, and (2) Low-dose fibrinolytic therapy combined with a glycoprotein (GP) IIb/IIIa inhibitor which can achieve higher rates of reperfusion than fibrinolytic therapy alone. In addition, the IIb/IIIa inhibitor as part of the reperfusion regimen will support any acute-phase interventions that are performed. The combination of fibrinolytic therapy and GP IIb/IIIa inhibition to "facilitate” PCI is being examined in TIMI-14, SPEED, and GUSTO IV. Early findings in the SPEED trial have shown promising results with "facilitated” PCI when patency is achieved before PCI is attempted. Results of these trials will further define the role of combination therapy in facilitating mechanical interventions. Kluwer Academic Publishers, 2000 glycoprotein IIb/IIIa inhibitors nationallicence thrombolysis nationallicence myocardial infarction nationallicence percutaneous coronary intervention nationallicence Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/3(2000-04-01), 235-241 0929-5305 9:3<235 2000 9 11239 https://doi.org/10.1023/A:1018714627681 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018714627681 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Cannon Christopher Cardiovascular Division of Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/3(2000-04-01), 235-241 0929-5305 9:3<235 2000 9 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer