caa a22 4500 475824059 CHVBK 20180406123826.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1023/A:1018762510842 doi (NATIONALLICENCE)springer-10.1023/A:1018762510842 Moderate Alcohol Consumption is Associated with Decreased Platelet Activity in Patients Presenting with Acute Myocardial Infarction [Elektronische Daten] [Victor Serebruany, David Lowry, Sergei Fuzailov, Douglas Levine, Christopher O'Connor, Paul Gurbel] Moderate alcohol consumption (MAC) and platelet inhibition have been independently associated with a reduced risk for the development of acute myocardial infarction (AMI). The effects of MAC on the initial platelet status in patients presenting with AMI are not elucidated. Here we sought to define the effects of MAC on platelet characteristics in AMI patients before applying any reperfusion strategies. The study was designed as an analysis within the cohort study in 23 patients with AMI enrolled in the GUSTO-III. Platelets were investigated by different techniques, including aggregometry, flow cytometry, and ELISA. MAC patients exhibited mild, but consistent, inhibition of platelet aggregability, surface receptor expression, and released substances as compared to non-alcohol consuming patients. These differences were significant for 5 µM ADP (p = 0.04), 10 µM ADP-induced aggregation (p = 0.02); P-selectin (p = 0.01), and PECAM-1 (p = 0.02) platelet-bound expression. Our study confirms that moderate alcohol consumption is associated with diminished platelet activation in patients presenting with AMI. The ability of MAC to favorably modulate the pre-reperfusion platelet status in such patients is of clinical importance, and further investigation in large-scale clinical trials seem warranted. Kluwer Academic Publishers, 2000 alcohol nationallicence platelets nationallicence acute myocardial infarction nationallicence human nationallicence Serebruany Victor Sinai Center for Thrombosis Research, Schapiro Research Building, Baltimore, Maryland aut Lowry David Sinai Center for Thrombosis Research, Schapiro Research Building, Baltimore, Maryland aut Fuzailov Sergei Sinai Center for Thrombosis Research, Schapiro Research Building, Baltimore, Maryland aut Levine Douglas Sinai Center for Thrombosis Research, Schapiro Research Building, Baltimore, Maryland aut O'Connor Christopher Division of Cardiology, Duke University Medical Center, Durham, North Carolina aut Gurbel Paul Sinai Center for Thrombosis Research, Schapiro Research Building, Baltimore, Maryland aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/3(2000-04-01), 229-234 0929-5305 9:3<229 2000 9 11239 https://doi.org/10.1023/A:1018762510842 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018762510842 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Serebruany Victor Sinai Center for Thrombosis Research, Schapiro Research Building, Baltimore, Maryland aut NATIONALLICENCE 700 1- Lowry David Sinai Center for Thrombosis Research, Schapiro Research Building, Baltimore, Maryland aut NATIONALLICENCE 700 1- Fuzailov Sergei Sinai Center for Thrombosis Research, Schapiro Research Building, Baltimore, Maryland aut NATIONALLICENCE 700 1- Levine Douglas Sinai Center for Thrombosis Research, Schapiro Research Building, Baltimore, Maryland aut NATIONALLICENCE 700 1- O'Connor Christopher Division of Cardiology, Duke University Medical Center, Durham, North Carolina aut NATIONALLICENCE 700 1- Gurbel Paul Sinai Center for Thrombosis Research, Schapiro Research Building, Baltimore, Maryland aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/3(2000-04-01), 229-234 0929-5305 9:3<229 2000 9 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer