caa a22 4500 475824075 CHVBK 20180406123826.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1023/A:1018766611751 doi (NATIONALLICENCE)springer-10.1023/A:1018766611751 Does Ultrasound Influence Experimentally Induced Thrombus Formation in the Central Artery of the Rabbit Ear? [Elektronische Daten] [Johan Nordquist, Jonas Carlson, Peter Dougan, S Olsson, Lars Salemark] Background: Thrombosis is one of the most important causes of morbidity in the medical field. Several independent in vitro studies have shown that the fibrinolytic process may be enhanced by ultrasound, but the effect of ultrasound on thrombus formation in vivo is unexplored. The present study was designed to investigate this matter. Methods: In a blind randomized study, standardized arteriotomies and intimectomies were performed on the central arteries of the ears of 25 rabbits. The rabbits were allocated to two groups, an untreated control group and a group treated with ultrasound (10 pulses of frequency 1 MHz and intensity 1 W/cm2 per millisecond giving an averaged intensity of 0.01 W/cm2). Immediately after reperfusion, patency was confirmed by a manual empty/refill test, after which blood-flow was monitored using ultrasonic flow-probes twice a minute for two hours. At two hours, patency was rechecked. Results: All vessels were patent at reperfusion, but only seven vessels (three control, four treated) were patent when flow-rate measurements started. At 2 h, patency-frequencies were 12/23 in the control group and 11/22 in the treated group. Flow-rate curves in patent vessels in both groups were similar. Microscopic investigation at one week showed no difference in thrombus accumulation. Conclusions: Ultrasound with the above characteristics does not significantly improve patency in vivo. Kluwer Academic Publishers, 2000 ultrasound nationallicence thrombolysis nationallicence microvascular surgery nationallicence blood-flow nationallicence ultrasonic flowmetry nationallicence Nordquist Johan Department of Plastic and Reconstructive Surgery, University Hospital MAS, Malmö, Sweden aut Carlson Jonas Department of Cardiology, Lund University, Lund, Sweden aut Dougan Peter Department of Experimental Research, University Hospital MAS, Malmö, Sweden aut Olsson S. Department of Cardiology, Lund University, Lund, Sweden aut Salemark Lars Department of Plastic and Reconstructive Surgery, University Hospital MAS, Malmö, Sweden aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/3(2000-04-01), 243-249 0929-5305 9:3<243 2000 9 11239 https://doi.org/10.1023/A:1018766611751 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018766611751 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nordquist Johan Department of Plastic and Reconstructive Surgery, University Hospital MAS, Malmö, Sweden aut NATIONALLICENCE 700 1- Carlson Jonas Department of Cardiology, Lund University, Lund, Sweden aut NATIONALLICENCE 700 1- Dougan Peter Department of Experimental Research, University Hospital MAS, Malmö, Sweden aut NATIONALLICENCE 700 1- Olsson S. Department of Cardiology, Lund University, Lund, Sweden aut NATIONALLICENCE 700 1- Salemark Lars Department of Plastic and Reconstructive Surgery, University Hospital MAS, Malmö, Sweden aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/3(2000-04-01), 243-249 0929-5305 9:3<243 2000 9 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer