caa a22 4500 475824083 CHVBK 20180406123826.0 cr unu---uuuuu 170329e20000401xx s 000 0 eng 10.1023/A:1018758409934 doi (NATIONALLICENCE)springer-10.1023/A:1018758409934 Circulating Levels of IL-1β, a Prothrombotic Cytokine, are Elevated in Unstable Angina Versus Stable Angina [Elektronische Daten] [Alan Simon, Shahram Yazdani, Weizheng Wang, Allan Schwartz, LeRoy Rabbani] Background: Multiple studies support a role for inflammation in the pathogenesis of coronary atherosclerosis and unstable cardiac syndromes. However, of the known proinflammatory cytokines, only elevated plasma levels of interleukin-6 have been linked to unstable angina. We sought to examine the plasma levels of other major proinflammatory cytokines in similar clinical settings and to determine the extent of the relationship between inflammation and unstable coronary syndromes by measuring the levels of various proinflammatory cytokines in patients with stable and unstable angina. Methods: We measured plasma levels of interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6) in 97 patients: 67 with stable angina, 24 with unstable angina, and 15 healthy controls. Results: Mean levels of IL-1β were significantly higher in patients with unstable angina as compared to patients with stable angina (p = .009). Levels of IL-6 were significantly higher than control patients for both stable angina and unstable angina patients (p = .031 and .006, respectively). No significant differences were found in the levels of TNF-α. Conclusions: Our results suggest that both IL-1β and IL-6 contribute to the pathogenesis of unstable angina, and that the profile of circulating plasma levels of proinflammatory cytokines differs in unstable angina from that in stable angina. Abbreviated Abstract. Multiple studies support a role for inflammation in the pathogenesis of coronary atherosclerosis and unstable cardiac syndromes. We measured plasma levels of interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6) in patients with stable and unstable coronary syndromes. Levels of IL-1β and IL-6 were found to be elevated in patients with unstable coronary syndromes. No significant differences were found in the levels of TNF-α. Our results suggest that both IL-1β and IL-6 contribute to the pathogenesis of unstable angina. Kluwer Academic Publishers, 2000 interleukins nationallicence unstable angina nationallicence stable angina nationallicence Simon Alan Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY aut Yazdani Shahram Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY aut Wang Weizheng Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY aut Schwartz Allan Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY aut Rabbani LeRoy Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/3(2000-04-01), 217-222 0929-5305 9:3<217 2000 9 11239 https://doi.org/10.1023/A:1018758409934 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018758409934 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Simon Alan Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY aut NATIONALLICENCE 700 1- Yazdani Shahram Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY aut NATIONALLICENCE 700 1- Wang Weizheng Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY aut NATIONALLICENCE 700 1- Schwartz Allan Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY aut NATIONALLICENCE 700 1- Rabbani LeRoy Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/3(2000-04-01), 217-222 0929-5305 9:3<217 2000 9 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer