caa a22 4500 47582427X CHVBK 20180406123827.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1023/A:1018718914065 doi (NATIONALLICENCE)springer-10.1023/A:1018718914065 High Platelet Count in Platelet-Rich Plasma Reduces Measured Platelet Inhibition by Abciximab but not Tirofiban nor Eptifibatide Glycoprotein IIb/IIIa Receptor Antagonists [Elektronische Daten] [Dean Kereiakes, Thomas Broderick, Eli Roth, David Whang, Michele Mueller, Pam Lacock, Linda Anderson, Wendy Howard, Chris Blanck, John Schneider, Charles Abbottsmith] We evaluated the differential effect of platelet count in platelet-rich plasma (PRP) on the level of ex vivo inhibition of platelet aggregation provided by abciximab, eptifibatide, and tirofiban as part of a randomized, comparative trial of these agents on platelet function in patients with unstable angina pectoris undergoing percutaneous coronary intervention. Platelet count <350 K/µL in PRP reduced measured platelet inhibition by abciximab, but not eptifibatide nor tirofiban. This observation suggests the need for standardized, uniform platelet counts in PRP during future comparisons of the degree of platelet inhibition by these agents. Kluwer Academic Publishers, 2000 Kereiakes Dean The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut Broderick Thomas Ohio Heart Health Center, Cincinnati, Ohio aut Roth Eli Ohio Heart Health Center, Cincinnati, Ohio aut Whang David The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut Mueller Michele The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut Lacock Pam The Health Alliance Laboratory Service, Cincinnati, Ohio, USA aut Anderson Linda The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut Howard Wendy The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut Blanck Chris The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut Schneider John The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut Abbottsmith Charles The Health Alliance Laboratory Service, Cincinnati, Ohio, USA aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/2(2000-02-01), 149-155 0929-5305 9:2<149 2000 9 11239 https://doi.org/10.1023/A:1018718914065 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018718914065 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kereiakes Dean The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut NATIONALLICENCE 700 1- Broderick Thomas Ohio Heart Health Center, Cincinnati, Ohio aut NATIONALLICENCE 700 1- Roth Eli Ohio Heart Health Center, Cincinnati, Ohio aut NATIONALLICENCE 700 1- Whang David The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut NATIONALLICENCE 700 1- Mueller Michele The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut NATIONALLICENCE 700 1- Lacock Pam The Health Alliance Laboratory Service, Cincinnati, Ohio, USA aut NATIONALLICENCE 700 1- Anderson Linda The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut NATIONALLICENCE 700 1- Howard Wendy The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut NATIONALLICENCE 700 1- Blanck Chris The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut NATIONALLICENCE 700 1- Schneider John The Carl and Edyth Lindner Center for Clinical Cardiovascular Research, Cincinnati, Ohio aut NATIONALLICENCE 700 1- Abbottsmith Charles The Health Alliance Laboratory Service, Cincinnati, Ohio, USA aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 9/2(2000-02-01), 149-155 0929-5305 9:2<149 2000 9 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer