caa a22 4500 475824377 CHVBK 20180406123827.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1023/A:1018790519492 doi (NATIONALLICENCE)springer-10.1023/A:1018790519492 The Decanucleotide Polymorphism in the Factor VII Promoter Predicts Factor VII Plasma Levels but not the Risk of Acute Coronary Syndromes [Elektronische Daten] [Ester Jimenez-Boj, Jörg Schüttrumpf, Eva Forberg, Herbert Watzke, Kurt Huber] It is known from large epidemiological studies that the elevation of coagulation factor VII in plasma is an independent risk factor for acute coronary syndromes. The level of factor VII is influenced by polymorphic sites in the factor VII gene. However, data on the association of such polymorphisms with the risk of acute coronary syndromes are conflicting. A decanucleotide insertion/deletion polymorphic site has been described in the promoter of the factor VII gene that leads to a dramatic change in the plasma factor VII levels. We therefore analyzed the association of this polymorphism with the risk of acute coronary syndromes in a case-control study. Included in the study were 111 patients with angiographically documented acute coronary syndromes and 108 age- and sex-matched individuals from the same geographic area without signs or symptoms of coronary heart disease. The presence or absence of the decanucleotide stretch at position −323 in the promoter of factor VII was monitored using a polymerase chain reaction (PCR)-based restriction technique. The prevalence of the genotype with the homozygous deletion was similar in the patients with acute coronary syndromes (79.2%) and in the control patients (79.6%). There was a non-significant trend toward a higher prevalence of the homozygote deletion in patients with premature acute coronary syndromes (77.4%) compared with an age-matched subgroup of the control patients (67.5%) (odds ratio [OR] 1.6, confidence interval [CI] 0.95, 0.61-3.93). Thus, we could not find a significant association of the ocurrence of acute coronary events with the insertion/deletion polymorphism in factor VII. Kluwer Academic Publishers, 2000 factor VII polymorphism nationallicence acute coronary syndromes nationallicence factor VII plasma level nationallicence cardiovascular risk factors nationallicence Jimenez-Boj Ester Division of Hematology and Hemostaseology, University of Vienna, Austria aut Schüttrumpf Jörg Division of Hematology and Hemostaseology, University of Vienna, Austria aut Forberg Eva Division of Hematology and Hemostaseology, University of Vienna, Austria aut Watzke Herbert Division of Hematology and Hemostaseology, University of Vienna, Austria aut Huber Kurt Division of Cardiology, University of Vienna, Austria aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10/1(2000-08-01), 23-28 0929-5305 10:1<23 2000 10 11239 https://doi.org/10.1023/A:1018790519492 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018790519492 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jimenez-Boj Ester Division of Hematology and Hemostaseology, University of Vienna, Austria aut NATIONALLICENCE 700 1- Schüttrumpf Jörg Division of Hematology and Hemostaseology, University of Vienna, Austria aut NATIONALLICENCE 700 1- Forberg Eva Division of Hematology and Hemostaseology, University of Vienna, Austria aut NATIONALLICENCE 700 1- Watzke Herbert Division of Hematology and Hemostaseology, University of Vienna, Austria aut NATIONALLICENCE 700 1- Huber Kurt Division of Cardiology, University of Vienna, Austria aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10/1(2000-08-01), 23-28 0929-5305 10:1<23 2000 10 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer