caa a22 4500 475824385 CHVBK 20180406123827.0 cr unu---uuuuu 170329e20000801xx s 000 0 eng 10.1023/A:1018763108106 doi (NATIONALLICENCE)springer-10.1023/A:1018763108106 Cutlip Donald The University of Rochester Medical Center, Rochester, NewYork, USA aut Stent Thrombosis: Historical Perspectives and Current Trends [Elektronische Daten] [Donald Cutlip] Coronary stents are now implanted in more than 70% of percutaneous coronary revascularization procedures. Early enthusiasm for improved acute angiographic results and limited restenosis was dampened initially by a high rate of stent thrombosis and later by the increased bleeding complications of aggressive and complex anticoagulation protocols designed to lower the stent thrombosis risk. More recently, routine high-pressure deployment strategies and anti-platelet drug regimens have lowered the incidence of stent thrombosis to approximately 1% without an increased bleeding risk. The timing of stent thrombosis has also changed from a median of 4-5 days to a median of 1 day after the stent procedure. Risk factors in earlier studies included stenting for threatened or abrupt closure, smaller vessels, longer lesions, and possibly left anterior descending artery lesion location. Modern studies have shown a slightly increased risk for multiple stent use, residual dissection, and smaller final lumen. Optimal therapy for stent thrombosis includes emergent revascularization and anti-thrombotic treatment, although the clinical consequences remain dire despite successful reperfusion. The use of platelet glycoprotein IIb/IIIa inhibitors, especially in high-risk situations may further reduce the incidence of stent thrombosis. Kluwer Academic Publishers, 2000 coronary artery nationallicence myocardial infarction nationallicence review nationallicence Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10/1(2000-08-01), 89-101 0929-5305 10:1<89 2000 10 11239 https://doi.org/10.1023/A:1018763108106 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018763108106 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Cutlip Donald The University of Rochester Medical Center, Rochester, NewYork, USA aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10/1(2000-08-01), 89-101 0929-5305 10:1<89 2000 10 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer