caa a22 4500 47582444X CHVBK 20180406123827.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1026551409350 doi (NATIONALLICENCE)springer-10.1023/A:1026551409350 Ticlopidine and Aspirin Fail to Suppress the Increased Platelet Aggregability That Follows Percutaneous Coronary Interventions [Elektronische Daten] [Dionigi Fischetti, Alessandro Sciahbasi, Antonio Leone, Giampaolo Niccoli, Giovanni Schiavoni, Carlo Trani, Mario Mazzari, Felicita Andreotti] Previous studies indicate that percutaneous transluminal coronary angioplasty (PTCA) is associated with platelet activation. It is not well-established whether enhanced platelet aggregability after PTCA is prevented by the association of ticlopidine with aspirin. The aim of this study was to evaluate whole blood platelet aggregability before and after elective PTCA in patients with chronic stable angina receiving ticlopidine and aspirin. We studied 16 patients referred for elective PTCA, treated for≥72 hours with oral aspirin and ticlopidine (group 1), and 10 patients referred for diagnostic coronary angiography, treated with oral aspirin alone (group 2). An intravenous bolus of heparin was administered at the start of PTCA. In both groups, platelet aggregability was assessed at baseline and 24 hours after the procedure, using the PFA 100® system. This method measures the time required for flowing whole blood to occlude a collagen and adenosine diphosphate (ADP)-coated ring, shorter times indicating greater aggregability. In both groups, platelet aggregability after the procedure was significantly increased compared with baseline: 104±30 seconds before versus 88±24 seconds at 24 hours in group 1 (p=0.03) and 84±16 seconds before versus 69±14 seconds at 24 hours in group 2 (p=0.004). Group 1 patients, compared with group 2, showed a trend toward reduced aggregability at baseline (p=0.06) and significantly lower aggregability 24 hours after the procedure (p=0.03). Ticlopidine and aspirin reduce whole-blood platelet aggregability compared with aspirin alone but fail to suppress the increased aggregability that occurs 24 hours after PTCA. Kluwer Academic Publishers, 2000 coronary angioplasty nationallicence chronic stable angina nationallicence platelet aggregability nationallicence ticlopidine nationallicence aspirin nationallicence Fischetti Dionigi Institute of Cardiology, Catholic University, Rome, Italy aut Sciahbasi Alessandro Institute of Cardiology, Catholic University, Rome, Italy aut Leone Antonio Institute of Cardiology, Catholic University, Rome, Italy aut Niccoli Giampaolo Institute of Cardiology, Catholic University, Rome, Italy aut Schiavoni Giovanni Institute of Cardiology, Catholic University, Rome, Italy aut Trani Carlo Institute of Cardiology, Catholic University, Rome, Italy aut Mazzari Mario Institute of Cardiology, Catholic University, Rome, Italy aut Andreotti Felicita Institute of Cardiology, Catholic University, Rome, Italy aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10/3(2000-12-01), 265-269 0929-5305 10:3<265 2000 10 11239 https://doi.org/10.1023/A:1026551409350 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026551409350 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fischetti Dionigi Institute of Cardiology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Sciahbasi Alessandro Institute of Cardiology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Leone Antonio Institute of Cardiology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Niccoli Giampaolo Institute of Cardiology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Schiavoni Giovanni Institute of Cardiology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Trani Carlo Institute of Cardiology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Mazzari Mario Institute of Cardiology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Andreotti Felicita Institute of Cardiology, Catholic University, Rome, Italy aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10/3(2000-12-01), 265-269 0929-5305 10:3<265 2000 10 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer