caa a22 4500 475824547 CHVBK 20180406123827.0 cr unu---uuuuu 170329e20001201xx s 000 0 eng 10.1023/A:1026503526188 doi (NATIONALLICENCE)springer-10.1023/A:1026503526188 The Treatment and Outcome of Cancer Patients with Thromboses on Central Venous Catheters [Elektronische Daten] [David Frank, Jennifer Meuse, Denise Hirsch, Joseph Ibrahim, Annick van den Abbeele] Thromboses are a common complication of central venous catheters in cancer patients. This study was performed to analyze retrospectively the treatment and outcome of all patients with venous thromboses related to central venous catheters at a major cancer center. From 1992 through 1995, 319 oncology patients with central venous catheters underwent radionuclide venography (RNV) at the Dana-Farber Cancer Institute for suspected catheter or venous thrombosis. The treatment and outcome of patients found to have venous thromboses were evaluated. Of the 319 patients, 112 were found to have evidence of venous thrombosis. The median age and platelet counts were not significantly different between the patients with and without thromboses. The most common indication for obtaining RNV was difficulty in aspirating or infusing material through the catheter. Patients who had pain or edema, or both, of the neck or upper extremity were more likely to have a venous thrombosis. Regardless of therapeutic intervention, including anticoagulation with heparin or coumadin, or both; line removal or replacement; or a combination thereof, no patients had a major adverse outcome such as pulmonary embolism, compromise of limb, or death. Only 4 patients did not have resolution of their presenting symptoms, all of whom were treated with line replacement. The overall survival of patients with and without thromboses was not significantly different. Either anticoagulation or removal of the central venous catheter (or both) appears to be adequate treatment for catheter-related thrombosis. A prospective trial to evaluate these approaches may be worthwhile so that the use of unnecessary procedures may be avoided in this patient population. Kluwer Academic Publishers, 2000 central venous catheter nationallicence thrombosis nationallicence cancer nationallicence radionuclide venography nationallicence Frank David Department of Adult Oncology, Dana-Farber Cancer Institute, USA aut Meuse Jennifer Department of Adult Oncology, Dana-Farber Cancer Institute, USA aut Hirsch Denise Pentucket Medical Associates, Newburyport aut Ibrahim Joseph Department of Biostatistics, Dana-Farber Cancer Institute, USA aut van den Abbeele Annick Department of Nuclear Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts, USA aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10/3(2000-12-01), 271-275 0929-5305 10:3<271 2000 10 11239 https://doi.org/10.1023/A:1026503526188 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1026503526188 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Frank David Department of Adult Oncology, Dana-Farber Cancer Institute, USA aut NATIONALLICENCE 700 1- Meuse Jennifer Department of Adult Oncology, Dana-Farber Cancer Institute, USA aut NATIONALLICENCE 700 1- Hirsch Denise Pentucket Medical Associates, Newburyport aut NATIONALLICENCE 700 1- Ibrahim Joseph Department of Biostatistics, Dana-Farber Cancer Institute, USA aut NATIONALLICENCE 700 1- van den Abbeele Annick Department of Nuclear Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts, USA aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10/3(2000-12-01), 271-275 0929-5305 10:3<271 2000 10 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer