caa a22 4500 475824571 CHVBK 20180406123828.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1023/A:1027320917297 doi (NATIONALLICENCE)springer-10.1023/A:1027320917297 Fundamental Concepts in the Pathobiology of Heparin-Induced Thrombocytopenia [Elektronische Daten] [James Januzzi Jr., Ik-Kyung Jang] Heparin-induced thrombocytopenia (HIT) is among the most common causes of drug-related immune-mediated thrombocytopenia. It is a unique syndrome, in that despite the fact that thrombocyto-penia is the major laboratory manifestation of HIT, its major complication is a highly morbid (and commonly fatal) thrombotic diathesis, known as the HIT with thrombosis syndrome (HITTS). The pathogenesis of HIT and HITTS has been recently elucidated, and involves an immune response against epitopes within circulating heparin-platelet factor-4 (PF4) complexes. This leads to cross-linking and activation of platelets, increasing the risk for thromboses. Furthermore, significant immunological cross-reactivity occurs between endothelial-cell bound PF4 and the HIT antibody, which may lead to endothelial damage, activation, and hyperplasia. This complex process leads to a hypercoagulable state, which may lead to overt thromboses. Kluwer Academic Publishers, 2000 heparin nationallicence thrombocytopenia nationallicence HIT nationallicence pathophysiology nationallicence Januzzi Jr. James Cardiology Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA aut Jang Ik-Kyung Cardiology Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10(2000-11-01), 7-11 0929-5305 10<7 2000 10 11239 https://doi.org/10.1023/A:1027320917297 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1027320917297 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Januzzi Jr James Cardiology Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA aut NATIONALLICENCE 700 1- Jang Ik-Kyung Cardiology Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10(2000-11-01), 7-11 0929-5305 10<7 2000 10 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer