caa a22 4500 475824636 CHVBK 20180406123828.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1023/A:1027341521840 doi (NATIONALLICENCE)springer-10.1023/A:1027341521840 Case Studies in Heparin-Induced Thrombocytopenia [Elektronische Daten] [Astrid Andreescu, Mary Cushman] Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications. Here, we present illustrative case histories to educate the reader on evaluation and management of this complex syndrome. Cases include typical and unusual presentations of the syndrome, and commonly encountered problems and pitfalls of therapy. Major points illustrated are, (1) occurrence of HIT with any dose or form of heparin; (2) misperceptions on the diagnostic criteria; (3) correct (thrombin inhibitors) and incorrect (platelet transfusions and warfarin) management; (4) influence of management strategy on clinical outcomes; (5) severity of the syndrome; and (6) potential for both anamnestic response to heparin and disappearance of HIT antibodies over time. Effective therapy of HIT involves both the prompt recognition of the syndrome and its proper management. Kluwer Academic Publishers, 2000 heparin nationallicence thrombocytopenia nationallicence clinical nationallicence Andreescu Astrid Department of Medicine, University of Vermont, Colchester, Vermont, USA aut Cushman Mary Department of Medicine, University of Vermont, Colchester, Vermont, USA aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10(2000-11-01), 71-76 0929-5305 10<71 2000 10 11239 https://doi.org/10.1023/A:1027341521840 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1027341521840 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andreescu Astrid Department of Medicine, University of Vermont, Colchester, Vermont, USA aut NATIONALLICENCE 700 1- Cushman Mary Department of Medicine, University of Vermont, Colchester, Vermont, USA aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10(2000-11-01), 71-76 0929-5305 10<71 2000 10 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer