caa a22 4500 475824644 CHVBK 20180406123828.0 cr unu---uuuuu 170329e20001101xx s 000 0 eng 10.1023/A:1027385304093 doi (NATIONALLICENCE)springer-10.1023/A:1027385304093 Becker Richard Cardiovascular Thrombosis Research Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA aut Hirudin-Based Anticoagulant Strategies for Patients with Suspected Heparin-Induced Thrombocytopenia Undergoing Percutaneous Coronary Interventions and Bypass Grafting [Elektronische Daten] [Richard Becker] Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse drug reaction that is associated with thrombotic events of the venous and arterial circulatory systems stemming from an intense and well-characterized prothrombotic triad of platelet activation, coagulation cascade stimulation and vascular endothelial cell injury. Although heparin (or other sulfated mucopolysaccharide compound) cessation represents a vital first step in management, patients remain susceptible to life-threatening thrombosis for up to several weeks, providing a strong rationale for a ‘proactive approach' to care that includes prompt initiation of an alternative anticoagulant strategy throughout the high-risk period. The importance of alternative options for anticoagulation is most evident in clinical situations wherein treatment is a recognized standard of care and prerequisite for an optimal outcome. The following review highlights the use of recombinant hirudin (lepirudin) among patients with suspected HIT requiring precutaneous coronary interventions (PCI) and coronary arterial bypass grafting. Kluwer Academic Publishers, 2000 heparin-induced thrombocytomis nationallicence hiruden nationallicence revascularization nationallicence Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10(2000-11-01), 59-68 0929-5305 10<59 2000 10 11239 https://doi.org/10.1023/A:1027385304093 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1027385304093 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Becker Richard Cardiovascular Thrombosis Research Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10(2000-11-01), 59-68 0929-5305 10<59 2000 10 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer