caa a22 4500 47582475X CHVBK 20180406123828.0 cr unu---uuuuu 170329e20001001xx s 000 0 eng 10.1023/A:1018714626726 doi (NATIONALLICENCE)springer-10.1023/A:1018714626726 Temporary Reversal of Anticoagulation Using Oral Vitamin K [Elektronische Daten] [Richard White, Stephen Minton, Michael Andya, Rose Hutchinson] Brief reversal of oral anticoagulant therapy is frequently necessary prior to minor surgery or invasive procedures. We sought to determine the effect of an oral dose of 2.0 mg of vitamin K1 on the international normalized ratio (INR) among patients with a stable therapeutic INR who were maintained on their daily dose of warfarin. We prospectively studied a convenience cohort of patients attending an anticoagulation clinic who had either just completed treatment for venous thromboembolism or were receiving prophylaxis for atrial fibrillation, cardiomyopathy, or peripheral vascular disease. Each patient received an oral dose of 2.0 mg of aqueous vitamin K1. Serial INR measurements were taken over 1 week. There was wide variation in the INR response between patients, from no change to complete reversal of anticoagulation. The effect also varied widely over time. There was a significant inverse correlation between the fall in logarithm of the INR and the daily warfarin dose required to achieve an INR value of 2.5 (r=−0.52, p=0.011). Use of a 2.0 mg oral dose of vitamin K1 does not reliably reverse (correct) a therapeutic INR in patients maintained on their daily dose of warfarin. Kluwer Academic Publishers, 2000 anticoagulation nationallicence warfarin nationallicence vitamin K nationallicence INR nationallicence White Richard University of California, Davis, Sacramento, California, USA aut Minton Stephen University of California, Davis, Sacramento, California, USA aut Andya Michael University of California, Davis, Sacramento, California, USA aut Hutchinson Rose University of California, Davis, Sacramento, California, USA aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10/2(2000-10-01), 149-153 0929-5305 10:2<149 2000 10 11239 https://doi.org/10.1023/A:1018714626726 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1023/A:1018714626726 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- White Richard University of California, Davis, Sacramento, California, USA aut NATIONALLICENCE 700 1- Minton Stephen University of California, Davis, Sacramento, California, USA aut NATIONALLICENCE 700 1- Andya Michael University of California, Davis, Sacramento, California, USA aut NATIONALLICENCE 700 1- Hutchinson Rose University of California, Davis, Sacramento, California, USA aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 10/2(2000-10-01), 149-153 0929-5305 10:2<149 2000 10 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer