caa a22 4500 475830938 CHVBK 20180406123839.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s100960050014 doi (NATIONALLICENCE)springer-10.1007/s100960050014 Epidemiology of Quinolone Resistance of Klebsiella pneumoniae and Klebsiella oxytoca in Europe [Elektronische Daten] [S. Brisse, D. Milatovic, A. C. Fluit, J. Verhoef, F.-J. Schmitz]  The epidemiology of quinolone resistance and the concomitant resistance to other antibiotic classes was investigated in 445 Klebsiella pneumoniae and 238 Klebsiella oxytoca isolates. Decreased susceptibility to ciprofloxacin was found in 7.2% and 3.4% of these two species, respectively. Ciprofloxacin resistance was significantly linked to ceftazidime resistance, the hallmark of extended-spectrum β-lactamase production, as well as to resistance to all antibiotic classes tested. Using automated ribotyping, seven intrahospital- and interhospital-transmitted clones of ciprofloxacin-resistant isolates were found. The newer fluoroquinolones sitafloxacin and clinafloxacin may become increasingly valuable, since they proved to be active also against ciprofloxacin-resistant isolates. Springer-Verlag Berlin Heidelberg, 2000 Brisse S. Eijkman-Winkler Institute, Utrecht University, AZU G04.614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands e-mail: sbrisse@lab.azu.nl, NL aut Milatovic D. Eijkman-Winkler Institute, Utrecht University, AZU G04.614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands e-mail: sbrisse@lab.azu.nl, NL aut Fluit A. C. Eijkman-Winkler Institute, Utrecht University, AZU G04.614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands e-mail: sbrisse@lab.azu.nl, NL aut Verhoef J. Eijkman-Winkler Institute, Utrecht University, AZU G04.614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands e-mail: sbrisse@lab.azu.nl, NL aut Schmitz F.-J Eijkman-Winkler Institute, Utrecht University, AZU G04.614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands e-mail: sbrisse@lab.azu.nl, NL aut https://doi.org/10.1007/s100960050014 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050014 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brisse S. Eijkman-Winkler Institute, Utrecht University, AZU G04.614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands e-mail: sbrisse@lab.azu.nl, NL aut NATIONALLICENCE 700 1- Milatovic D. Eijkman-Winkler Institute, Utrecht University, AZU G04.614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands e-mail: sbrisse@lab.azu.nl, NL aut NATIONALLICENCE 700 1- Fluit A. C. Eijkman-Winkler Institute, Utrecht University, AZU G04.614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands e-mail: sbrisse@lab.azu.nl, NL aut NATIONALLICENCE 700 1- Verhoef J. Eijkman-Winkler Institute, Utrecht University, AZU G04.614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands e-mail: sbrisse@lab.azu.nl, NL aut NATIONALLICENCE 700 1- Schmitz F.-J Eijkman-Winkler Institute, Utrecht University, AZU G04.614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands e-mail: sbrisse@lab.azu.nl, NL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer