caa a22 4500 475830962 CHVBK 20180406123839.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s100960050011 doi (NATIONALLICENCE)springer-10.1007/s100960050011 Clinical Significance of Scedosporium apiospermum in Patients with Cystic Fibrosis [Elektronische Daten] [B. Cimon, J. Carrère, J. F. Vinatier, J. P. Chazalette, D. Chabasse, J. P. Bouchara]  The incidence of airway colonization by Scedosporium apiospermum and of related sensitization was investigated prospectively in 128 patients with cystic fibrosis over a 5-year period, and results were compared with clinical data. Scedosporium apiospermum, recovered from sputum samples in 11 of 128 (8.6%) patients, was the most frequent filamentous fungus after Aspergillus fumigatus. Counterimmunoelectrophoresis, used to detect scedosporiosis serologically, was positive in 27 of 128 (21.1%) patients. The discrepancy between the mycological and serological results may be related to immune cross-reactions between Scedosporium apiospermum and Aspergillus fumigatus. However, symptoms of allergic bronchopulmonary disease were observed in two patients chronically colonized by Scedosporium apiospermum. The results clearly demonstrate that the frequency of this fungus is largely underestimated and that it may trigger an inflammatory response, thus suggesting a pathogenic role in patients with cystic fibrosis. Springer-Verlag Berlin Heidelberg, 2000 Cimon B. Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01, France e-mail: Becimon@chu-angers.fr, FR aut Carrère J. Hôpital Renée Sabran, Giens, 83406 Hyères Cedex, France, FR aut Vinatier J. F. Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01, France e-mail: Becimon@chu-angers.fr, FR aut Chazalette J. P. Hôpital Renée Sabran, Giens, 83406 Hyères Cedex, France, FR aut Chabasse D. Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01, France e-mail: Becimon@chu-angers.fr, FR aut Bouchara J. P. Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01, France e-mail: Becimon@chu-angers.fr, FR aut https://doi.org/10.1007/s100960050011 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050011 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cimon B. Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01, France e-mail: Becimon@chu-angers.fr, FR aut NATIONALLICENCE 700 1- Carrère J. Hôpital Renée Sabran, Giens, 83406 Hyères Cedex, France, FR aut NATIONALLICENCE 700 1- Vinatier J. F. Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01, France e-mail: Becimon@chu-angers.fr, FR aut NATIONALLICENCE 700 1- Chazalette J. P. Hôpital Renée Sabran, Giens, 83406 Hyères Cedex, France, FR aut NATIONALLICENCE 700 1- Chabasse D. Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01, France e-mail: Becimon@chu-angers.fr, FR aut NATIONALLICENCE 700 1- Bouchara J. P. Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, 4 rue Larrey, 49033 Angers Cedex 01, France e-mail: Becimon@chu-angers.fr, FR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer