caa a22 4500 475831012 CHVBK 20180406123839.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s100960050002 doi (NATIONALLICENCE)springer-10.1007/s100960050002 Factors Associated with Nosocomial Diarrhea and Clostridium difficile -Associated Disease on the Adult Wards of an Urban Tertiary Care Hospital [Elektronische Daten] [M. J. Schwaber, A. Simhon, C. Block, V. Roval, N. Ferderber, M. Shapiro]  A prospective survey of the adult inpatient population of an urban tertiary care hospital was conducted to determine factors associated with the development of nosocomial diarrhea and the acquisition of Clostridium difficile-associated disease. During the 3-month survey, 98 patients with nosocomial diarrhea were enrolled, and 38 controls were recruited. The controls were patients without diarrhea lying in beds adjacent to the affected patients. Factors significantly associated with nosocomial diarrhea were the administration of a special diet (P=0.02) and receipt of a greater number of different antibiotics (P=0.02). Among the 98 patients with diarrhea, Clostridium difficile toxin B was identified in the stool of 13. Factors found to be associated with the presence of toxin B as compared to other causes of nosocomial diarrhea were a greater number of individual antibiotics used during hospitalization (P=0.02) and receipt of a cephalosporin (P=0.03) or, more specifically, a third-generation cephalosporin (P=0.02). Among patients with nosocomial diarrhea, those who had toxin in their stool had a significantly higher total antibiotic burden (expressed as antibiotic days) than those with diarrhea due to other causes (P=0.01). Springer-Verlag Berlin Heidelberg, 2000 Schwaber M. J. Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel, IL aut Simhon A. Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel, IL aut Block C. Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel, IL aut Roval V. Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel, IL aut Ferderber N. Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel, IL aut Shapiro M. Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel, IL aut https://doi.org/10.1007/s100960050002 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050002 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schwaber M. J. Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel, IL aut NATIONALLICENCE 700 1- Simhon A. Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel, IL aut NATIONALLICENCE 700 1- Block C. Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel, IL aut NATIONALLICENCE 700 1- Roval V. Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel, IL aut NATIONALLICENCE 700 1- Ferderber N. Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel, IL aut NATIONALLICENCE 700 1- Shapiro M. Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, PO Box 12000, Jerusalem 91120, Israel, IL aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer