caa a22 4500 475831055 CHVBK 20180406123839.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s100960050008 doi (NATIONALLICENCE)springer-10.1007/s100960050008 Cluster of Cases of Mycobacterium chelonae Bacteraemia [Elektronische Daten] [D. McCracken, P. Flanagan, D. Hill, I. Hosein]  Mycobacterium chelonae was isolated from the blood of four immunosuppressed patients over a period of 10 weeks. Three patients had intravascular catheters in situ and the other had a biliary stent. All presented with recurrent fever despite treatment with broad-spectrum antibiotics. Blood cultures using standard bacteriological medium yielded a gram-positive bacillus from each patient. Ziehl-Neelsen staining of these cultures demonstrated a branching acid-fast bacillus that was subsequently identified as Mycobacterium chelonae in each case. The isolates were sensitive to clarithromycin and, although success of treatment with clarithromycin monotherapy has been variable, this antibiotic combined with removal of the intravascular catheters was used to treat those three patients. The treatment was successful with no recurrence of symptoms after 12 months of follow-up. The patient with the biliary stent died soon after Mycobacterium chelonae was isolated. Pyrolysis mass spectrometry analysis indicated the isolates were of two distinct strains. Radiological insertion of the Hickman lines and biliary stent was implicated epidemiologically as the source of infection. Springer-Verlag Berlin Heidelberg, 2000 McCracken D. Regional Centre for Mycobacteriology, Department of Microbiology and Public Health Laboratory, University Hospital of Wales, Cardiff CF4 4XW, UK e-mail: mccrackend@cf.ac.uk, GB aut Flanagan P. Regional Centre for Mycobacteriology, Department of Microbiology and Public Health Laboratory, University Hospital of Wales, Cardiff CF4 4XW, UK e-mail: mccrackend@cf.ac.uk, GB aut Hill D. Infection Prevention and Control Department, Department of Microbiology and Public Health Laboratory, University Hospital of Wales, Cardiff, UK, GB aut Hosein I. Infection Prevention and Control Department, Department of Microbiology and Public Health Laboratory, University Hospital of Wales, Cardiff, UK, GB aut https://doi.org/10.1007/s100960050008 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050008 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McCracken D. Regional Centre for Mycobacteriology, Department of Microbiology and Public Health Laboratory, University Hospital of Wales, Cardiff CF4 4XW, UK e-mail: mccrackend@cf.ac.uk, GB aut NATIONALLICENCE 700 1- Flanagan P. Regional Centre for Mycobacteriology, Department of Microbiology and Public Health Laboratory, University Hospital of Wales, Cardiff CF4 4XW, UK e-mail: mccrackend@cf.ac.uk, GB aut NATIONALLICENCE 700 1- Hill D. Infection Prevention and Control Department, Department of Microbiology and Public Health Laboratory, University Hospital of Wales, Cardiff, UK, GB aut NATIONALLICENCE 700 1- Hosein I. Infection Prevention and Control Department, Department of Microbiology and Public Health Laboratory, University Hospital of Wales, Cardiff, UK, GB aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer