caa a22 4500 47583108X CHVBK 20180406123839.0 cr unu---uuuuu 170329e20000201xx s 000 0 eng 10.1007/s100960050004 doi (NATIONALLICENCE)springer-10.1007/s100960050004 Long-Term Outcome of Acute Hepatitis B and C in an Outbreak of Hepatitis in 1969-72 [Elektronische Daten] [J. Bläckberg, J. H. Braconier, A. Widell, K. Kidd-Ljunggren]  The objective of this study was to investigate the epidemiology, etiology, and long-term outcome of an extended outbreak of acute hepatitis that occurred in an area of Sweden between 1969 and 1972. The outbreak was analyzed retrospectively by retesting stored frozen serum samples for the presence of hepatitis A, B and C markers. The results were compared with the diagnoses that had been determined during the outbreak. Of 180 patients, 29 (16%) had acute hepatitis A, 126 (70%) had acute hepatitis B, and eight (4.4%) had acute hepatitis C. The Australia antigen test used during the outbreak had failed to identify 21 patients with acute hepatitis B virus infection. Genotyping of the hepatitis B virus strains showed that genotype D was the most prevalent, irrespective of the transmission route. An attempt was made to follow up patients with unresolved hepatitis B virus infection, 25-27 years after the acute infection. None of the 100 patients with acute hepatitis B infection who were traced had become chronic carriers. In ten patients with hepatitis C virus infection, the follow-up showed considerable variation in the outcome, ranging from spontaneous resolution to death through liver cirrhosis. Intravenous drug users had a high prevalence of hepatitis C virus infection, with 52% testing positive for hepatitis C antibodies. Springer-Verlag Berlin Heidelberg, 2000 Bläckberg J. Department of Infectious Diseases, University Hospital, 22185 Lund, Sweden e-mail: Jonas.Blackberg@infek.lu.se, SE aut Braconier J. H. Department of Infectious Diseases, University Hospital, 22185 Lund, Sweden e-mail: Jonas.Blackberg@infek.lu.se, SE aut Widell A. Department of Clinical Virology, Malmö University Hospital, 21401 Malmö, Sweden, SE aut Kidd-Ljunggren K. Department of Virology, Umeå University, 90185 Umeå, Sweden, SE aut https://doi.org/10.1007/s100960050004 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960050004 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bläckberg J. Department of Infectious Diseases, University Hospital, 22185 Lund, Sweden e-mail: Jonas.Blackberg@infek.lu.se, SE aut NATIONALLICENCE 700 1- Braconier J. H. Department of Infectious Diseases, University Hospital, 22185 Lund, Sweden e-mail: Jonas.Blackberg@infek.lu.se, SE aut NATIONALLICENCE 700 1- Widell A. Department of Clinical Virology, Malmö University Hospital, 21401 Malmö, Sweden, SE aut NATIONALLICENCE 700 1- Kidd-Ljunggren K. Department of Virology, Umeå University, 90185 Umeå, Sweden, SE aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer