caa a22 4500 475831209 CHVBK 20180406123840.0 cr unu---uuuuu 170329e20000701xx s 000 0 eng 10.1007/s100960000236 doi (NATIONALLICENCE)springer-10.1007/s100960000236 Analysis of Risk Factors for Ventilator-Associated Pneumonia in a Multidisciplinary Intensive Care Unit [Elektronische Daten] [D. C. Sofianou, T. C. Constandinidis, M. Yannacou, H. Anastasiou, E. Sofianos]  A prospective study was conducted to determine the incidence, risk factors and pathogens of ventilator-associated pneumonia (VAP) in 198 patients requiring mechanical ventilation for more than 48 hours. VAP occurred in 67 (33.8%) patients. Risk factors associated with VAP were admission APACHE II score >20 (odds ratio [OR] 4.77, 95% confidence interval [CI] 2.04-11.27, P<0.001), mechanical ventilation >10 days (OR 44.4, 95% CI 2.16-26.7, P<0.0001), ICU length of stay >10 days (OR 9.4, 95% CI 3.55-25.65, P<0.0001), and admission PaO2/FiO2 ratio <200 mmHg (OR 3.4, 95% CI 1.00-11.41, P<0.05). Logistic regression analysis showed a relationship between VAP and length of stay in ICU, duration of fever and presence of catheter-related infection. The pathogens isolated were predominantly gram-negative bacteria (83.2%), with a high proportion of Acinetobacter spp. (35%) resistant to commonly used antimicrobial agents. The mortality rate was not influenced by VAP. Springer-Verlag Berlin Heidelberg, 2000 Sofianou D. C. Department of Medical Microbiology, Aristotle University of Thessaloniki, Thessaloniki, Greece, GR aut Constandinidis T. C. Department of Hygiene and Epidemiology, Aristotle University of Thessaloniki, Thessaloniki, Greece, GR aut Yannacou M. Department of Anesthesiology, Intensive Care Unit, AHEPA General University Hospital, 1 St. Kiriakidi Street, 546 36 Thessaloniki, Greece, GR aut Anastasiou H. Department of Anesthesiology, Intensive Care Unit, AHEPA General University Hospital, 1 St. Kiriakidi Street, 546 36 Thessaloniki, Greece, GR aut Sofianos E. Department of Anesthesiology, Intensive Care Unit, AHEPA General University Hospital, 1 St. Kiriakidi Street, 546 36 Thessaloniki, Greece, GR aut https://doi.org/10.1007/s100960000236 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s100960000236 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sofianou D. C. Department of Medical Microbiology, Aristotle University of Thessaloniki, Thessaloniki, Greece, GR aut NATIONALLICENCE 700 1- Constandinidis T. C. Department of Hygiene and Epidemiology, Aristotle University of Thessaloniki, Thessaloniki, Greece, GR aut NATIONALLICENCE 700 1- Yannacou M. Department of Anesthesiology, Intensive Care Unit, AHEPA General University Hospital, 1 St. Kiriakidi Street, 546 36 Thessaloniki, Greece, GR aut NATIONALLICENCE 700 1- Anastasiou H. Department of Anesthesiology, Intensive Care Unit, AHEPA General University Hospital, 1 St. Kiriakidi Street, 546 36 Thessaloniki, Greece, GR aut NATIONALLICENCE 700 1- Sofianos E. Department of Anesthesiology, Intensive Care Unit, AHEPA General University Hospital, 1 St. Kiriakidi Street, 546 36 Thessaloniki, Greece, GR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer